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躁狂症

Mania

作者信息

Dailey Mark W., Saadabadi Abdolreza

机构信息

Western University/ Kaweah Delta

Abstract

Mania, or a manic phase, is a period of 1 week or more in which a person experiences a change in behavior that drastically affects their functioning. Mania is different from hypomania because hypomania does not cause a major deficit in social or occupational functioning, and it is a period of at least 4 days rather than 1 week. The defining characteristics of mania are increased talkativeness, rapid speech, decreased need for sleep, racing thoughts, distractibility, increase in goal-directed activity, and psychomotor agitation. Some other hallmarks of mania are an elevated or expansive mood, mood lability, impulsivity, irritability, and grandiosity. If the individual experiencing these symptoms requires hospitalization, then this period automatically qualifies as true mania and not hypomania, even if the symptoms are present for less than one week. Mania must be distinguished from heightened energy and altered functioning that arises from substance use, medical conditions, or other causes. Mania is a "natural" state which is the characteristic of bipolar I disorder. A single manic phase is sufficient to make the diagnosis of bipolar I disorder, although most cases of bipolar I also involve hypomanic and depressed episodes. Many families bring their loved ones to the emergency room due to the excessive behavioral changes they have noticed over a brief period. Patients amid a manic phase commonly engage in goal-directed activities that may result in harmful consequences, such as spending excessive money, starting businesses unprepared, traveling, or promiscuity. Many patients engage in property damage or even harm themselves or others through verbal or physical assaults. They may also become highly aggressive, agitated, or irritable. Although the patient may have poor insight and may not recognize they are behaving out of the norm, it becomes apparent to family or friends that this behavior may be due to mental illness. Mania also commonly presents with psychotic features, which include delusions or hallucinations. Many patients endorse grandiose delusions, believing they are high-level operatives such as spies, government officials, members of secret agencies, or that they are knowledgeable professionals (even when they have no such background). These individuals may also experience auditory or visual hallucinations, which only present when they are in the manic phases. Some of the most common delusions are delusions of paranoia, in which patients believe that people are stalking, targeting, or surveilling them. They may believe this to be done by government agencies, gangs, or others. These patients are highly unlikely to respond to outsiders’ views on their psychosis as well as their mania. A component of the manic phase is that generally, the individuals themselves do not realize what is happening (poor insight). The problem is mainly noticed by others, including family members, friends, and even strangers or police. Rapid cycling in bipolar disorder is defined as having at least 4 or more mood episodes in a 12-month period. These mood episodes may be manic, hypomanic, or depressive but must meet their full diagnostic and duration criteria. These episodes must be separated by periods of partial or full remission of at least 2 months or be separated by a switch to an episode of opposite polarities, such as mania or hypomania to major depressive episodes. Switching from mania to hypomania or vice-versa would not qualify because they are not opposite polarity. Rapid cycling bipolar disorder patients have been found to be more resistant to pharmacotherapy.

摘要

躁狂发作期,或躁狂阶段,是指持续1周或更长时间的一段时期,在此期间,一个人的行为发生变化,严重影响其正常功能。躁狂与轻躁狂不同,因为轻躁狂不会导致社交或职业功能出现重大缺陷,且持续时间至少为4天而非1周。躁狂的典型特征包括健谈、语速加快、睡眠需求减少、思维奔逸、注意力分散、目标导向活动增加以及精神运动性激越。躁狂的其他一些特征包括情绪高涨或夸张、情绪不稳定、冲动、易怒和夸大观念。如果出现这些症状的个体需要住院治疗,那么即使症状持续时间不足一周,这一时期也自动符合真正躁狂的标准,而非轻躁狂。必须将躁狂与因物质使用、躯体疾病或其他原因引起的精力充沛和功能改变区分开来。躁狂是双相I型障碍的一种“自然”状态。单次躁狂发作期就足以诊断双相I型障碍,尽管大多数双相I型障碍病例还包括轻躁狂发作和抑郁发作。许多家庭会因其亲人在短时间内出现的过度行为变化而将他们送往急诊室。处于躁狂发作期的患者通常会进行一些目标导向活动,这些活动可能会导致有害后果,比如过度消费、贸然创业、出行或行为不检。许多患者会造成财产损失,甚至通过言语或身体攻击伤害自己或他人。他们也可能会变得极具攻击性、烦躁不安或易怒。尽管患者可能自知力差,可能意识不到自己的行为超出了正常范围,但家人或朋友会明显看出这种行为可能是由精神疾病引起的。躁狂发作通常还伴有精神病性症状,包括妄想或幻觉。许多患者存在夸大妄想,认为自己是高级特工,如间谍、政府官员、秘密机构成员,或者认为自己是知识渊博的专业人士(即使他们并无此类背景)。这些个体也可能会出现听觉或视觉幻觉,且仅在躁狂发作期出现。一些最常见的妄想是偏执妄想,患者认为有人在跟踪、针对或监视他们。他们可能认为这是政府机构、帮派或其他人所为。这些患者极不可能认同外界对其精神病性症状及躁狂症状的看法。躁狂发作期的一个特点是,通常个体自身并未意识到发生了什么(自知力差)。问题主要是由他人发现的,包括家庭成员、朋友,甚至陌生人或警察。双相障碍中的快速循环被定义为在12个月内至少有4次或更多次情绪发作。这些情绪发作可能是躁狂发作、轻躁狂发作或抑郁发作,但必须符合其完整的诊断标准和持续时间标准。这些发作之间必须有至少2个月的部分或完全缓解期,或者由转换为相反极性的发作隔开,如从躁狂发作或轻躁狂发作转换为重度抑郁发作。从躁狂发作转换为轻躁狂发作或反之则不符合标准,因为它们不是相反极性。已发现快速循环型双相障碍患者对药物治疗的反应较差。

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