褪黑素在再生医学中的多重功能。
The multiple functions of melatonin in regenerative medicine.
机构信息
Solid Tumor Research Center, Urmia University of Medical Sciences, Urmia, Iran.
Department of Cellular and Structural Biology, The University of Texas Health Science Center, San Antonio, TX, USA.
出版信息
Ageing Res Rev. 2018 Aug;45:33-52. doi: 10.1016/j.arr.2018.04.003. Epub 2018 Apr 6.
Melatonin research has been experiencing hyper growth in the last two decades; this relates to its numerous physiological functions including anti-inflammation, oncostasis, circadian and endocrine rhythm regulation, and its potent antioxidant activity. Recently, a large number of studies have focused on the role of melatonin in the regeneration of cells or tissues after their partial loss. In this review, we discuss the recent findings on the molecular involvement of melatonin in the regeneration of various tissues including the nervous system, liver, bone, kidney, bladder, skin, and muscle, among others.
褪黑素研究在过去二十年中经历了高速发展；这与其众多的生理功能有关，包括抗炎、肿瘤抑制、调节昼夜节律和内分泌节律，以及其强大的抗氧化活性。最近，大量研究集中在褪黑素在细胞或组织部分损失后的再生中的作用。在这篇综述中，我们讨论了褪黑素在包括神经系统、肝脏、骨骼、肾脏、膀胱、皮肤和肌肉等各种组织再生中的分子作用的最新发现。
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