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褪黑素对涡虫头部再生的影响取决于暴露的时间和持续时长。

Effects of melatonin on planaria head regeneration are dependent on both timing and duration of exposure.

作者信息

Beeching Simon C, Ruland Hanna E, Sparks Katelyn M

机构信息

Department of Biology, Slippery Rock University of Pennsylvania, Slippery Rock, Pennsylvania, USA.

出版信息

Physiol Rep. 2025 Jan;13(2):e70151. doi: 10.14814/phy2.70151.

DOI:10.14814/phy2.70151
PMID:39838534
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11750803/
Abstract

Melatonin is a multifunctional biomolecule with demonstrated stimulatory, inhibitory, and antioxidant effects, including both receptor-mediated and receptor-independent mechanisms of action. One of its more perplexing effects is the disruption of regeneration in planaria. Head regeneration in planaria is a remarkable phenomenon in which stem cells (neoblasts) migrate to the wound site, proliferate, then differentiate into all functional tissue types within days of injury. We investigated how both the timing and duration of melatonin exposure affect head regeneration in the planaria Phagocata gracilis (Haldeman). Our results demonstrate that P. gracilis is capable of recovery from the melatonin-induced delay of regeneration and reveal the time required to recover to control levels. Further, we found evidence of regenerative stage-specific responses to discontinuous melatonin exposure, including non-inhibitory effects. Further exploration of melatonin's effects on regeneration can be targeted to specific regenerative processes, and the possibility of multiple mechanisms of action should be recognized.

摘要

褪黑素是一种多功能生物分子，具有已证实的刺激、抑制和抗氧化作用，包括受体介导和非受体介导的作用机制。其更令人困惑的作用之一是干扰涡虫的再生。涡虫的头部再生是一个显著的现象，其中干细胞（新生细胞）迁移到伤口部位，增殖，然后在受伤后的几天内分化为所有功能组织类型。我们研究了褪黑素暴露的时间和持续时间如何影响纤细食蜗蛭（哈迪曼）的头部再生。我们的结果表明，纤细食蜗蛭能够从褪黑素诱导的再生延迟中恢复，并揭示了恢复到对照水平所需的时间。此外，我们发现了对间歇性褪黑素暴露的再生阶段特异性反应的证据，包括非抑制作用。对褪黑素对再生影响的进一步探索可以针对特定的再生过程，并且应该认识到多种作用机制的可能性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f8a/11750803/b3023a16483f/PHY2-13-e70151-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f8a/11750803/b6cbeb0617c9/PHY2-13-e70151-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f8a/11750803/f2e163cca38f/PHY2-13-e70151-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f8a/11750803/9e9f0650daf7/PHY2-13-e70151-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f8a/11750803/e83e62dd631e/PHY2-13-e70151-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f8a/11750803/28d5c261764b/PHY2-13-e70151-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f8a/11750803/c8de0ab4238c/PHY2-13-e70151-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f8a/11750803/a3b61ba8604b/PHY2-13-e70151-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f8a/11750803/456229915fbb/PHY2-13-e70151-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f8a/11750803/b3023a16483f/PHY2-13-e70151-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f8a/11750803/b6cbeb0617c9/PHY2-13-e70151-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f8a/11750803/f2e163cca38f/PHY2-13-e70151-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f8a/11750803/9e9f0650daf7/PHY2-13-e70151-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f8a/11750803/e83e62dd631e/PHY2-13-e70151-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f8a/11750803/28d5c261764b/PHY2-13-e70151-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f8a/11750803/c8de0ab4238c/PHY2-13-e70151-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f8a/11750803/a3b61ba8604b/PHY2-13-e70151-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f8a/11750803/456229915fbb/PHY2-13-e70151-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f8a/11750803/b3023a16483f/PHY2-13-e70151-g006.jpg

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本文引用的文献

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Melatonin, tunneling nanotubes, mesenchymal cells, and tissue regeneration.褪黑素、隧道纳米管、间充质细胞与组织再生
Neural Regen Res. 2023 Apr;18(4):760-762. doi: 10.4103/1673-5374.353480.
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Regeneration Potential of Jellyfish: Cellular Mechanisms and Molecular Insights.水母的再生潜力：细胞机制与分子见解。
Genes (Basel). 2021 May 17;12(5):758. doi: 10.3390/genes12050758.
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Melatonin suppresses both osteoblast and osteoclast differentiation through repression of epidermal Erk signaling in the zebrafish scale.褪黑素通过抑制斑马鱼鳞片表皮 Erk 信号通路抑制成骨细胞和破骨细胞分化。
Biochem Biophys Res Commun. 2020 Oct 1;530(4):644-650. doi: 10.1016/j.bbrc.2020.07.075. Epub 2020 Aug 5.
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Melatonin-stimulated MSC-derived exosomes improve diabetic wound healing through regulating macrophage M1 and M2 polarization by targeting the PTEN/AKT pathway.褪黑素刺激 MSC 来源的外泌体通过靶向 PTEN/AKT 通路调节巨噬细胞 M1 和 M2 极化来改善糖尿病创面愈合。
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