CNR Institute of Neuroscience, Via L. Vanvitelli, 32-20129 Milano, Italy.
CNR Institute of Neuroscience, Via L. Vanvitelli, 32-20129 Milano, Italy.
Mol Cell Neurosci. 2018 Sep;91:76-81. doi: 10.1016/j.mcn.2018.04.001. Epub 2018 Apr 6.
Tetraspanins are a family of proteins largely expressed in mammals. These proteins share very similar structures and are involved in several biological processes spanning from the immune system to cancer growth regulation. Moreover, tetraspanins are scaffold proteins that are able to interact with each other and with a subset of proteins involved in the regulation of the central nervous system, including synapse formation, function and plasticity. In this review, we will focus on the analysis of the literature on tetraspanins, highlighting their involvement in synapse formation and function through direct or indirect modulation of synaptic proteins.
四跨膜蛋白是一类在哺乳动物中广泛表达的蛋白质家族。这些蛋白质具有非常相似的结构，参与了从免疫系统到癌症生长调节等多种生物学过程。此外，四跨膜蛋白是支架蛋白，能够相互作用，也能够与一组参与中枢神经系统调节的蛋白质相互作用，包括突触形成、功能和可塑性。在这篇综述中，我们将重点分析关于四跨膜蛋白的文献，强调它们通过直接或间接调节突触蛋白在突触形成和功能中的作用。
