Matthews C J, Searle R F
Department of Anatomy, Medical School, Newcastle upon Tyne, U.K.
J Reprod Immunol. 1987 Oct;12(2):109-24. doi: 10.1016/0165-0378(87)90039-8.
Supernatants from short-term cultures of murine decidual tissue (DS) were assessed for their regulatory effects on T cell lymphoproliferation and cytotoxic T lymphocyte (CTL) activity. DS non-specifically suppressed antigen- and mitogen-induced lymphoproliferation, spontaneous thymocyte proliferation, the mixed lymphocyte reaction (MLR) and CTL generation, but had no effect on CTL lytic activity. The immunosuppressive activity was lost after dialysis (14 kDa cut off). Supernatants from indomethacin-treated decidual tissue cultures (indomethacin-DS) lacked suppressive activity in the MLR, mitogen and thymocyte proliferation assays. Indomethacin-DS also showed markedly reduced or no suppressive effects on CTL generation. These findings suggest that prostaglandin production by the decidual component of the placenta could play a role in materno-fetal cellular interactions by regulating T cell lymphoproliferative responses and CTL generation.
对小鼠蜕膜组织（DS）短期培养的上清液进行评估，以检测其对T细胞淋巴细胞增殖和细胞毒性T淋巴细胞（CTL）活性的调节作用。DS非特异性抑制抗原和丝裂原诱导的淋巴细胞增殖、自发性胸腺细胞增殖、混合淋巴细胞反应（MLR）和CTL生成，但对CTL裂解活性无影响。透析（截留分子量14 kDa）后，免疫抑制活性丧失。吲哚美辛处理的蜕膜组织培养物（吲哚美辛-DS）的上清液在MLR、丝裂原和胸腺细胞增殖试验中缺乏抑制活性。吲哚美辛-DS对CTL生成也显示出明显降低或无抑制作用。这些发现表明，胎盘蜕膜成分产生的前列腺素可能通过调节T细胞淋巴细胞增殖反应和CTL生成，在母胎细胞相互作用中发挥作用。
