Stewart I J, Mitchell B S
Faculty of Medicine, University of Southampton, UK.
J Anat. 1991 Dec;179:183-96.
The spatiotemporal distribution of macrophages in the uterine wall of virgin mice and mice in the first half of pregnancy has been studied. Macrophages were identified using a combination of morphological criteria, the capacity to endocytose horseradish peroxidase and the expression of the Mac-1 antigen. In virgin mice and mice at preimplantation stages of pregnancy, macrophages were found throughout the endometrium, myometrium and mesometrial triangle. Following implantation, and in parallel with decidualisation, the density of macrophages appeared to decline in the decidua with advancing gestation. It is suggested that this change in density is due to a dilution of the macrophage population rather than a loss of individual cells. The numbers and distribution of decidual macrophages indicate that this group of cells does not play a major regulatory role in the success of pregnancy.
已对未孕小鼠和妊娠前半期小鼠子宫壁中巨噬细胞的时空分布进行了研究。通过形态学标准、内吞辣根过氧化物酶的能力以及Mac-1抗原的表达相结合的方法来鉴定巨噬细胞。在未孕小鼠和妊娠植入前阶段的小鼠中，巨噬细胞存在于整个子宫内膜、子宫肌层和子宫系膜三角区。植入后，随着蜕膜化，蜕膜中巨噬细胞的密度似乎随着妊娠进展而下降。有人认为，这种密度变化是由于巨噬细胞群体的稀释而非单个细胞的丢失所致。蜕膜巨噬细胞的数量和分布表明，这群细胞在妊娠成功过程中并不起主要调节作用。
