Essack Zaynab, Wassenaar Douglas R
1 HIV AIDS Vaccines Ethics Group (HAVEG), University of KwaZulu-Natal, Pietermaritzburg, South Africa.
2 Human Sciences Research Council, Pietermaritzburg, South Africa.
J Empir Res Hum Res Ethics. 2018 Jul;13(3):239-246. doi: 10.1177/1556264618763422. Epub 2018 Apr 9.
HIV prevention trials provide a prevention package to participants to help prevent HIV acquisition. As new prevention methods are proven effective, this raises ethical and scientific design complexities regarding the prevention package or standard of prevention. Given its high HIV incidence and prevalence, South Africa has become a hub for HIV prevention research. For this reason, it is critical to study the implementation of relevant ethical-legal frameworks for such research in South Africa. This qualitative study used in-depth interviews to explore the practices and perspectives of eight members of South African research ethics committees (RECs) who have reviewed protocols for HIV vaccine trials. Their practices and perspectives are compared with ethics guideline requirements for standards of prevention.
艾滋病病毒预防试验为参与者提供一整套预防措施，以帮助预防感染艾滋病病毒。随着新的预防方法被证明有效，这在预防措施组合或预防标准方面引发了伦理和科学设计的复杂性。鉴于南非艾滋病病毒的高发病率和高流行率，该国已成为艾滋病病毒预防研究的中心。因此，研究南非此类研究相关伦理法律框架的实施情况至关重要。这项定性研究采用深入访谈的方式，探讨了南非研究伦理委员会（RECs）的八名成员的做法和观点，这些成员曾审查过艾滋病病毒疫苗试验的方案。将他们的做法和观点与预防标准的伦理准则要求进行了比较。
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