1 Department of Internal Medicine, Division of Endocrinology, General Hospital Sint-Jan Brugge-Oostende , Bruges, Belgium .
2 Department of Radiology, General Hospital Sint-Jan Brugge-Oostende , Bruges, Belgium .
Thyroid. 2018 Jun;28(6):769-772. doi: 10.1089/thy.2017.0651. Epub 2018 May 11.
Amiodarone-induced thyrotoxicosis is a common complication of long-term amiodarone treatment. In a patient with amiodarone-induced lung toxicity and amiodarone-induced thyrotoxicosis type 2 (AIT2), a "white thyroid" was incidentally observed on an unenhanced chest computed tomography (CT) scan. This "white thyroid" resembled a thyroid image on a contrast-enhanced CT scan. Therefore, the thyroid density was prospectively evaluated on unenhanced CT scans in cases of AIT2, in euthyroid patients on amiodarone (AEuth), and in unexposed controls. The aim was to test the hypothesis of a higher thyroid density in AIT2 compared to AEuth. The thyroid density, as measured in Hounsfield Units on unenhanced CT scans, is higher in AIT2 compared to AEuth and much higher than in controls. The causality of this association and its potential diagnostic use require further study.
胺碘酮相关性甲亢是胺碘酮长期治疗的常见并发症。在一位患有胺碘酮相关性肺毒性和胺碘酮相关性 2 型甲亢（AIT2）的患者中，在未增强胸部 CT 扫描上偶然观察到“白色甲状腺”。这种“白色甲状腺”类似于增强 CT 扫描上的甲状腺图像。因此，前瞻性地在 AIT2 患者（AIT2）、服用胺碘酮但甲状腺功能正常的患者（AEuth）和未暴露对照者的未增强 CT 扫描上评估甲状腺密度，以检验 AIT2 患者的甲状腺密度高于 AEuth 的假设。与 AEuth 相比，未增强 CT 扫描上的甲状腺密度在 AIT2 患者中更高，并且明显高于对照组。这种关联的因果关系及其潜在的诊断用途需要进一步研究。
