Department of Cardiology, Shengjing Hospital of China Medical University, Shenyang, 110004, China.
Department of Cardiology, the First Hospital of China Medical University, 155 North Nanjing Street, Shenyang, 110001, China.
Lipids Health Dis. 2018 Apr 10;17(1):72. doi: 10.1186/s12944-018-0727-3.
Stroke has a high fatality and disability rate, and is one of the main burdens to human health. It is thus very important to identify biomarkers for the development of effective approaches for the prevention and treatment of stroke. Connexin37 is an anti-inflammatory cytokine and is involved in chronic inflammation and atherosclerosis. Recent studies have found that CONNEXIN37 gene variations are associated with atherosclerosis diseases, such as coronary heart disease and stroke, but its association with stroke in distinct human populations remains to be determined. We report here the analysis of the association of the single nucleotide polymorphisms (SNPs) of CONNEXIN37 with ischemic stroke in Han Chinese population.
Two SNPs of CONNEXIN37 gene were analyzed in 385 ischemic stroke patients and 362 hypertension control patients using ligase detection reaction (LDR) method.
Logistic regression analysis demonstrated that, AG and GG genotypes of SNP rs1764390 and CC genotype of rs1764391 of CONNEXIN37 were associated with an increased risk of ischemic stroke, and that G allele of rs1764390 is a risk factor for ischemic stroke. Further, we found that SNP rs1764390 and SNP rs1764391 in CONNEXIN37 were associated with ischemic stroke under additive/dominant model, and recessive/dominant model, respectively.
Our results indicate that CONNEXIN37 gene polymorphism is an ischemic stroke risk factor in Northern Han Chinese.
中风具有高死亡率和高致残率，是人类健康的主要负担之一。因此，识别用于预防和治疗中风的有效方法的生物标志物非常重要。连接蛋白 37 是一种抗炎细胞因子，参与慢性炎症和动脉粥样硬化。最近的研究发现，连接蛋白 37 基因变异与动脉粥样硬化疾病（如冠心病和中风）有关，但它与不同人群中风的关系仍有待确定。我们在此报告分析连接蛋白 37 单核苷酸多态性（SNP）与汉族人群缺血性中风的关联。
采用连接酶检测反应（LDR）法分析 385 例缺血性中风患者和 362 例高血压对照组中连接蛋白 37 基因的两个 SNP。
Logistic 回归分析表明，连接蛋白 37 的 SNP rs1764390 的 AG 和 GG 基因型和 rs1764391 的 CC 基因型与缺血性中风的风险增加相关，并且 rs1764390 的 G 等位基因是缺血性中风的危险因素。此外，我们发现连接蛋白 37 的 SNP rs1764390 和 SNP rs1764391 与缺血性中风在相加/显性模型和隐性/显性模型下相关。
我们的结果表明，连接蛋白 37 基因多态性是北方汉族缺血性中风的危险因素。
