Kumar Pradeep, Kumar Amit, Srivastava Mukesh Kumar, Misra Shubham, Pandit Awadh Kishor, Prasad Kameshwar
Department of Neurology, All India Institute of Medical Sciences, New Delhi, India.
Department of Neurobiochemistry, All India Institute of Medical Sciences, New Delhi, India.
Basic Clin Neurosci. 2016 Apr;7(2):91-6. doi: 10.15412/J.BCN.03070202.
Transforming Growth Factor-Beta 1 (TGF-β1) is a pleiotropic cytokine with potent anti-inflammatory property, which has been considered as an essential risk factor in the inflammatory process of Ischemic Stroke (IS), by involving in the pathophysiological progression of hypertension, atherosclerosis, and lipid metabolisms. -509C/T TGF-β1 gene polymorphism has been found to be associated with the risk of IS. The aim of this meta-analysis was to provide a relatively comprehensive account of the relation between -509C/T gene polymorphisms of TGF-β1 and susceptibility to IS.
A review of literature for eligible genetic association Studies published before October 20, 2014 was conducted in the PubMed, EMBASE, Google Scholar and Trip database. The strength of association was calculated by pooled odds ratios (ORs) with 95% confidence intervals using RevMan 5.3 software. Heterogeneity was examined using Higgins I-squared, Tau-squared, and Chi-squared tests.
A total of 2 studies involving 614 cases and 617 controls were found. The overall estimates did not show any significant relation between TGF-β1-509C/T polymorphism and risk of IS under dominant (CC+CT vs. TT: OR=1.01, 95%CI=0.31 to 3.26; P=0.99), recessive (CC vs. CT+TT: OR=0.94, 95%CI=0.47 to 1.90; P=0.87), and allelic models (T vs. C: OR=1.06, 95%CI=0.55 to 2.04; P=0.86).
This meta-analysis showed that TGF-β1-509C/T gene polymorphism has no significant association with the susceptibility of IS. Further well-designed prospective studies with larger sample size are needed to confirm these findings.
转化生长因子-β1（TGF-β1）是一种具有强大抗炎特性的多效细胞因子，通过参与高血压、动脉粥样硬化和脂质代谢的病理生理进展，被认为是缺血性中风（IS）炎症过程中的一个重要危险因素。已发现TGF-β1基因-509C/T多态性与IS风险相关。本荟萃分析的目的是相对全面地阐述TGF-β1基因-509C/T多态性与IS易感性之间的关系。
在PubMed、EMBASE、谷歌学术和Trip数据库中检索了2014年10月20日前发表的符合条件的基因关联研究文献。使用RevMan 5.3软件通过合并比值比（OR）及95%置信区间计算关联强度。采用Higgins I²、Tau²和卡方检验检测异质性。
共纳入2项研究，涉及614例病例和617例对照。总体估计显示，在显性模型（CC + CT与TT比较：OR = 1.01，95%CI = 0.31至3.26；P = 0.99）、隐性模型（CC与CT + TT比较：OR = 0.94，95%CI = 0.47至1.90；P = 0.87）和等位基因模型（T与C比较：OR = 1.06，95%CI = 0.55至2.04；P = 0.86）下，TGF-β1 - 509C/T多态性与IS风险之间均无显著关联。
本荟萃分析表明，TGF-β1 - 509C/T基因多态性与IS易感性无显著关联。需要进一步开展设计良好、样本量更大的前瞻性研究来证实这些发现。
