Meador-Woodruff J, Knobloch M, Vaudry H, Seidah N G, Watson S J, Akil H
Mental Health Research Institute, University of Michigan Medical Center, Ann Arbor 48109-0720.
NIDA Res Monogr. 1986;75:307-10.
The content and extent of processing of gamma-3-MSH and beta-endorphin were determined in the anterior (AL) and intermediate (IL) lobes of three monkey pituitaries. The peptides existed in equimolar amounts in each lobe. The processing of gamma-3-MSH paralleled that of beta-endorphin in each lobe; the primary products in AL were beta-lipotropin and a 9K form of gamma MSH, whereas in IL the predominant products were N-acetyl-beta-endorphin and gamma-3-MSH.