Gianoulakis C
Department of Psychiatry, McGill University, Douglas Hospital Research Centre, Verdun, Quebec, Canada.
NIDA Res Monogr. 1986;75:595-8.
Pregnant rats received subcutaneous implantation of either morphine or placebo pellets at various stages of gestation. Untreated animals served as basic controls. The effect of morphine treatment on the growth of the offspring as well as on the ontogeny of beta-endorphin in the pituitary gland and the hypothalamus was investigated. Results obtained indicated that pregnant rats treated with morphine from day 1 of pregnancy to day 21 presented complete resorption. Subcutaneous implantation of a morphine pellet on days 11, 13 and 19 of gestation allowed pregnancy to term, however the post-natal mortality rate was very high. Implantation of a morphine pellet on days 9 and 13 of gestation allowed pregnancy to term and after birth the withdrawal reaction of the offspring was mild and the mortality rate was low. At early stages of development there were differences in the pituitary and hypothalamic beta-endorphin content between the offspring of the morphine treated animals and the offspring of the control animals, but by day 22 no significant differences among the various groups were noticed.
怀孕大鼠在妊娠的不同阶段接受皮下植入吗啡或安慰剂药丸。未接受治疗的动物作为基础对照。研究了吗啡治疗对后代生长以及垂体和下丘脑β-内啡肽个体发生的影响。获得的结果表明，从妊娠第1天至第21天用吗啡治疗的怀孕大鼠出现完全吸收。在妊娠第11、13和19天皮下植入吗啡药丸可使妊娠足月，然而产后死亡率非常高。在妊娠第9和13天植入吗啡药丸可使妊娠足月，出生后后代的戒断反应轻微且死亡率低。在发育早期，吗啡治疗动物的后代与对照动物的后代之间垂体和下丘脑β-内啡肽含量存在差异，但到第22天，各组之间未发现显著差异。
