Fujimoto Manabu
Department of Dermatology, Faculty of Medicine, University of Tsukuba.
Brain Nerve. 2018 Apr;70(4):427-438. doi: 10.11477/mf.1416201015.
Recent studies have identified novel dermatomyositis-specific autoantibodies and revealed that disease-specific autoantibodies become positive at a high rate in this disease. Moreover, these autoantibodies have been demonstrated to show a strong correlation with distinct clinical manifestations and complications such as interstitial lung disease and malignancy. Thus, these autoantibodies are now recognized as useful tools to classify this varied disease into more homogeneous subsets. In this review, the clinical significance of five dermatomyositis-specific autoantibodies, anti-Mi-2, anti-MDA5, anti-TIF1, anti-NXP2, and anti-SAE, was described.
近期研究已鉴定出新型皮肌炎特异性自身抗体，并揭示疾病特异性自身抗体在该疾病中呈高阳性率。此外，这些自身抗体已被证明与诸如间质性肺病和恶性肿瘤等不同的临床表现及并发症密切相关。因此，这些自身抗体现在被认为是将这种多样疾病分类为更均匀亚组的有用工具。在本综述中，描述了五种皮肌炎特异性自身抗体，即抗Mi-2、抗MDA5、抗TIF1、抗NXP2和抗SAE的临床意义。
