Division of Developmental Neurology, Department of Paediatrics, University Medical Center Groningen, Groningen, the Netherlands.
SEIN Centre of Excellence for Epilepsy and Sleep Medicine, Zwolle, the Netherlands.
Dev Med Child Neurol. 2018 Nov;60(11):1149-1155. doi: 10.1111/dmcn.13761. Epub 2018 Apr 6.
Evidence is accumulating that motor and cognitive development are interrelated. This study investigates associations between motor development in infancy and cognitive function at 4 years of age.
This study is part of the Groningen prospective cohort study on the development of children born after assisted reproductive techniques such as in vitro fertilization. The study group consisted of 223 children (119 males, 104 females) born to subfertile couples (median gestational age 39.6wks, range 30-43wks). Motor behaviour was assessed with the Infant Motor Profile (IMP) at 4 months, 10 months, and 18 months. IQ was evaluated at 4 years with the Kaufman Assessment Battery for Children, Second Edition. Latent class growth modelling was used to analyse relations between IMP and IQ scores.
Infants with low total IMP scores had an IQ that was 8.9 points lower at 4 years than infants with typical IMP scores (95% confidence interval 3.6-14.1). Also, low scores in the domains of variation and performance were associated with a lower IQ at 4 years of age, by 6.1 points and 13.2 points respectively.
Motor development in relatively low-risk infants is associated with cognition at 4 years of age. In particular, low motor variation and performance are associated with a lower IQ at 4 years of age.
Motor development in infancy is directly related to cognitive function at 4 years of age. This relationship is most pronounced for infant motor variation and performance. The size of the differences in IQ is clinically relevant.
越来越多的证据表明运动和认知发展是相互关联的。本研究旨在调查婴儿期运动发育与 4 岁时认知功能之间的关系。
本研究是格罗宁根辅助生殖技术（如体外受精）后出生的儿童发展前瞻性队列研究的一部分。研究组包括 223 名儿童（男性 119 名，女性 104 名），其父母为生育能力低下的夫妇（中位胎龄 39.6 周，范围 30-43 周）。采用婴儿运动概况（IMP）在 4 个月、10 个月和 18 个月时评估运动行为。智商在 4 岁时采用 Kaufman 儿童评估量表第二版进行评估。采用潜在类别增长模型分析 IMP 和智商得分之间的关系。
总 IMP 得分较低的婴儿在 4 岁时的智商比典型 IMP 得分的婴儿低 8.9 分（95%置信区间 3.6-14.1）。此外，在变异性和表现性领域得分较低的婴儿在 4 岁时的智商也分别低 6.1 分和 13.2 分。
相对低风险婴儿的运动发育与 4 岁时的认知能力有关。特别是，婴儿运动变异性和表现性较低与 4 岁时的智商较低有关。
婴儿期的运动发育与 4 岁时的认知功能直接相关。这种关系在婴儿运动变异性和表现性方面最为显著。智商差异的大小具有临床意义。
