Kamal Nasser, Sanad Zakaria, Elkelani Osama, Rezk Mohamed, Shawky Mohamed, Sharaf Abd-Elbar
a Department of Obstetrics and Gynecology, Faculty of Medicine , Menoufia University , Shebin El-Kom , Egypt.
b Department of Radiology, Faculty of Medicine , Menoufia University , Shebin El-Kom , Egypt.
Gynecol Endocrinol. 2018 Sep;34(9):789-792. doi: 10.1080/09513590.2018.1459549. Epub 2018 Apr 10.
This prospective cohort study was conducted on 80 patients with clomiphene citrate (CC)-resistant polycystic ovary syndrome undergoing laparoscopic ovarian drilling (LOD). Pre- and post-LOD ovarian reserve parameters (anti-Mullerian hormone: AMH, ovarian volume: OV, and antral follicle count: AFC) and ovarian stromal blood flow indices (Vascularization index: VI, flow index: FI, and vascularization flow index: VFI) were measured to explore the effect of LOD and to find out the correlation between serum AMH and different clinical, hormonal, and ultrasonic variables. There was a highly significant reduction of the serum AMH (p < .001) after LOD with significant reduction in OV, AFC and vascular indices (VI, FI and VFI) of the right and left ovaries (p < .05). LOD significantly reduced ovarian reserve parameters (AMH, OV and AFC) and ovarian stromal blood flow indices (VI, FI and VFI) with no observed correlation between AMH levels and Doppler indices.
本前瞻性队列研究对80例克罗米芬柠檬酸盐（CC）抵抗型多囊卵巢综合征患者进行了腹腔镜卵巢打孔术（LOD）。测量LOD前后的卵巢储备参数（抗苗勒管激素：AMH、卵巢体积：OV和窦卵泡计数：AFC）以及卵巢基质血流指数（血管化指数：VI、血流指数：FI和血管化血流指数：VFI），以探讨LOD的效果，并找出血清AMH与不同临床、激素和超声变量之间的相关性。LOD后血清AMH显著降低（p < 0.001），左右卵巢的OV、AFC和血管指数（VI、FI和VFI）也显著降低（p < 0.05）。LOD显著降低了卵巢储备参数（AMH、OV和AFC）以及卵巢基质血流指数（VI、FI和VFI），未观察到AMH水平与多普勒指数之间存在相关性。
