Zaman Muhammad, Saeed-Ul-Hassan Syed, Sarfraz Rai Muhammad, Batool Nighat, Qureshi Muhammad Junaid, Akram Muhammad Abdullah, Munir Saiqa, Danish Zeeshan
Acta Pol Pharm. 2016 Nov;73(6):1415-1425.
The present time is considered as an era of advancements in drug delivery systems. Different novel approaches are under investigation that range from uniparticulate to multi particulate system, macro to micro and nano particulate systems. Pelletization is one of the novel drug delivery technique that provides an effective way to deliver the drug in modified pattern. It is advantageous in providing site specific delivery of the drug. Drugs with unpleasant taste, poor bioavailability and short biological half-life can be delivered efficiently through pellets. Their reduced size makes them more valuable as compared to the conventional drug deliv- ery system. Different techniques are used to fabricate the pellets such as extrusion and spheronization, hot melt extrusion, powder layering, suspension or solution layering, freeze pelletization and pelletization by direct compression method. Various natural polymers including xanthan gum, guar gum, tragacanth and gum acacia, semisynthetic polymers like cellulose derivatives, synthetic polymers like derivatives of acrylamides, can be used in pellets formulation. Information provided in this review is collected from various national and intemational research articles, review articles and literature available in the books. The purpose of the current review is to discuss pellets, their characterizations, different techniques of pelletization and the polymers with potential of being suitable for pellets formulation.
当前被认为是药物递送系统取得进展的时代。正在研究不同的新方法，范围从不单粒到多粒系统，从宏观到微观和纳米粒系统。制粒是一种新型药物递送技术，它提供了一种以改良方式递送药物的有效方法。它在实现药物的部位特异性递送方面具有优势。具有不良味道、低生物利用度和短生物半衰期的药物可以通过颗粒有效地递送。与传统药物递送系统相比，它们减小的尺寸使其更具价值。使用不同的技术来制造颗粒，如挤出滚圆法、热熔挤出、粉末层积、悬浮或溶液层积、冷冻制粒以及直接压片法制粒。各种天然聚合物，包括黄原胶、瓜尔胶、刺梧桐树胶和阿拉伯胶，半合成聚合物如纤维素衍生物，合成聚合物如丙烯酰胺衍生物，都可用于颗粒制剂。本综述中提供的信息收集自各种国内和国际研究文章、综述文章以及书籍中的文献。当前综述的目的是讨论颗粒、它们的表征、不同的制粒技术以及具有适合颗粒制剂潜力的聚合物。
