从泰国博他仑府食用动物中分离出的产超广谱β-内酰胺酶的多重耐药性肠炎沙门氏菌
MULTIDRUG RESISTANT AND EXTENDED SPECTRUM b-LACTAMASE PRODUCING SALMONELLA ENTERICA ISOLATED FROM FOOD ANIMALS IN PHATTHALUNG, THAILAND.
作者信息
Lertworapreecha Monthon, Noomee Sirilak, Sutthimusik Suparat, Utarapichat Bussakorn, Tontikapong Kumchai
出版信息
Southeast Asian J Trop Med Public Health. 2016 Nov;47(6):1257-69.
This study investigated antimicrobial resistance profiles and genes of b-lactamase-producing Salmonella enterica, isolates from animal feces and meat samples at small-scale rural farms in Phatthalung Province, Thailand. Of 40 isolates from swine feces 50%, 47%, 17%, 17%, and 15% were resistant to ampicillin, streptomycin, nalidixic acid, tetracycline, and chloramphenicol, respectively; of 29 isolates from chicken feces 33%, 27%, 7%, and 3% were resistant to streptomycin, nalidixic acid, tetracycline, and ampicillin, respectively; and of 6 isolates from cattle feces 67% were resistant to sulfamethoxazole and tetracycline, and 33% resistant to ampicillin, nalidixic acid and streptomycin. Of the 23 isolates from chicken meat 96%, 96%, 78%, 73%, 61%, 30%, and 9% were resistant to sulfamethoxazole, streptomycin, ampicillin, tetracycline, nalidixic acid, chloramphenicol, and ciprofloxacin, respectively; and of 31 isolates from pork meat 87%, 77%, 39%, 32%, 10% and 10% were resistant to sulfamethoxazole, tetracycline, streptomycin, ampicillin, nalidixic acid, and chloramphenicol, respectively. Three ampicillin-resistant isolates from swine feces carried the same extended-spectrum b-lactamase gene belonging to blaCTX-M group 1. The results of this study confirm the existence of ESBL in S. enterica isolated from food animals. Occurrence of an ESBL producing strain of S. enterica constitutes a public health threat through transmission of these strains to humans via contaminated food or transfer of antimicrobial resistant genes to human pathogens.
本研究调查了泰国博他伦府小规模乡村农场动物粪便和肉类样本中产β-内酰胺酶的肠炎沙门氏菌的抗菌药物耐药谱及耐药基因。从猪粪便中分离出的40株菌株中，分别有50%、47%、17%、17%和15%对氨苄西林、链霉素、萘啶酸、四环素和氯霉素耐药；从鸡粪便中分离出的29株菌株中，分别有33%、27%、7%和3%对链霉素、萘啶酸、四环素和氨苄西林耐药；从牛粪便中分离出的6株菌株中，67%对磺胺甲恶唑和四环素耐药，33%对氨苄西林、萘啶酸和链霉素耐药。从鸡肉中分离出的23株菌株中，分别有96%、96%、78%、73%、61%、30%和9%对磺胺甲恶唑、链霉素、氨苄西林、四环素、萘啶酸、氯霉素和环丙沙星耐药；从猪肉中分离出的31株菌株中，分别有87% 、77%、39%、32%、10%和10%对磺胺甲恶唑、四环素、链霉素、氨苄西林、萘啶酸和氯霉素耐药。从猪粪便中分离出的3株氨苄西林耐药菌株携带相同的属于blaCTX-M-1组的超广谱β-内酰胺酶基因。本研究结果证实了从食用动物分离出的肠炎沙门氏菌中存在超广谱β-内酰胺酶。肠炎沙门氏菌产超广谱β-内酰胺酶菌株的出现，通过受污染食物将这些菌株传播给人类或使抗菌药物耐药基因转移至人类病原体，对公众健康构成威胁。
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