Key Laboratory of Superlight Materials and Surface Technology, Ministry of Education, College of Material Sciences and Chemical Engineering , Harbin Engineering University , Harbin 150001 , P. R. China.
Key Laboratory of the Ministry of Education for Advanced Catalysis Materials , Zhejiang Normal University , Jinhua , Zhejiang 321004 , P. R. China.
Inorg Chem. 2018 May 7;57(9):4864-4876. doi: 10.1021/acs.inorgchem.7b02959. Epub 2018 Apr 10.
Multifunctional nanotheranostic agent with high performance for tumor site-specific generation of singlet oxygen (O) as well as imaging-guidance is crucial to laser-mediated photodynamic therapy. Here, we introduced a versatile strategy to design a smart nanoplatform using phase change material (PCM) to encapsulate photosensitizer (zinc phthalocyanine, ZnPc) in copper sulfide loaded Fe-doped tantalum oxide (Fe-mTaO@CuS) nanoparticles. When irradiated by 808 nm laser, the PCM is melted due to the hyperthermia effect from CuS nanoparticles, inducing the release of ZnPc to produce toxic O triggered by 650 nm light with very low power density (5 mW/cm). Then, the produced heat and toxic O can kill tumor cells in vitro and in vivo effectively. Furthermore, the special properties of Fe-mTaO endow the nanoplatform with excellent computed tomography (CT) and T-weighted magnetic resonance imaging ( T-MRI) performance for guiding and real-time monitoring of therapeutic effect. This work presents a feasible way to design smart nanoplatform for controllable generation of heat and O, achieving CT/ T-MRI dual-modal imaging-guided phototherapy.
多功能纳米诊疗剂具有在肿瘤部位特异性生成单线态氧（1O2）的高性能，以及成像指导对于激光介导的光动力治疗至关重要。在这里，我们介绍了一种通用策略，使用相变材料（PCM）来设计一种智能纳米平台，将光敏剂（锌酞菁，ZnPc）封装在负载硫化铜的铁掺杂钽氧化物（Fe-mTaO@CuS）纳米颗粒中。当用 808nm 激光照射时，由于 CuS 纳米粒子的热效应，PCM 被熔化，导致 ZnPc 释放，产生由 650nm 光触发的有毒 1O2，其功率密度非常低（5mW/cm）。然后，产生的热量和有毒 1O2 可以有效地在体外和体内杀死肿瘤细胞。此外，Fe-mTaO 的特殊性质赋予了纳米平台出色的计算机断层扫描（CT）和 T 加权磁共振成像（T-MRI）性能，用于指导和实时监测治疗效果。这项工作提出了一种设计可控产热和 1O2 的智能纳米平台的可行方法，实现了 CT/T-MRI 双模式成像引导的光疗。
