Ifijen Ikhazuagbe H, Christopher Awoyemi Taiwo, Lekan Ogunnaike Korede, Aworinde Omowunmi Rebecca, Faderin Emmanuel, Obembe Oluwafunke, Abdulsalam Akanji Tawakalitu Folashade, Igboanugo Juliet C, Udogu Uzochukwu, Ogidi Godwin Onogwu, Iorkula Terungwa H, Osayawe Osasere Jude-Kelly
Department of Research Outreach, Rubber Research Institute of Nigeria Iyanomo Benin City Nigeria
Laboratory Department, Covenant University Medical Centre Canaan land, KM 10, Idiroko Road Ota Ogun State Nigeria.
RSC Adv. 2024 Oct 23;14(46):33681-33740. doi: 10.1039/d4ra05732e.
Tantalum-based nanoparticles (TaNPs) have emerged as promising tools in cancer management, owing to their unique properties that facilitate innovative imaging and photothermal therapy applications. This review provides a comprehensive overview of recent advancements in TaNPs, emphasizing their potential in oncology. Key features include excellent biocompatibility, efficient photothermal conversion, and the ability to integrate multifunctional capabilities, such as targeted drug delivery and enhanced imaging. Despite these advantages, challenges remain in establishing long-term biocompatibility, optimizing therapeutic efficacy through surface modifications, and advancing imaging techniques for real-time monitoring. Strategic approaches to address these challenges include surface modifications like PEGylation to improve biocompatibility, precise control over size and shape for effective photothermal therapy, and the development of biodegradable TaNPs for safe elimination from the body. Furthermore, integrating advanced imaging modalities-such as photoacoustic imaging, magnetic resonance imaging (MRI), and computed tomography (CT)-enable real-time tracking of TaNPs , which is crucial for clinical applications. Personalized medicine strategies that leverage biomarkers and genetic profiling also hold promise for tailoring TaNP-based therapies to individual patient profiles, thereby enhancing treatment efficacy and minimizing side effects. In conclusion, TaNPs represent a significant advancement in nanomedicine, poised to transform cancer treatment paradigms while expanding into various biomedical applications.
基于钽的纳米颗粒（TaNP）因其独特性质助力创新成像和光热治疗应用，已成为癌症治疗领域颇具前景的工具。本文综述了TaNP的最新进展，着重介绍了其在肿瘤学中的潜力。关键特性包括出色的生物相容性、高效的光热转换以及整合多功能的能力，如靶向给药和增强成像。尽管具有这些优势，但在建立长期生物相容性、通过表面修饰优化治疗效果以及推进实时监测成像技术方面仍存在挑战。应对这些挑战的策略包括通过聚乙二醇化等表面修饰提高生物相容性、精确控制尺寸和形状以实现有效的光热治疗，以及开发可生物降解的TaNP以便从体内安全清除。此外，整合光声成像、磁共振成像（MRI）和计算机断层扫描（CT）等先进成像模式能够实时追踪TaNP，这对临床应用至关重要。利用生物标志物和基因谱分析的个性化医疗策略也有望根据个体患者情况定制基于TaNP的治疗方案，从而提高治疗效果并将副作用降至最低。总之，TaNP代表了纳米医学的重大进展，有望改变癌症治疗模式并拓展至各种生物医学应用领域。
