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ACE2 and pACE2: A Pair of Aces for Pulmonary Arterial Hypertension Treatment?

作者信息

Richards Elaine M, Raizada Mohan K

机构信息

1 Department of Physiology and Functional Genomics University of Florida College of Medicine Gainesville, Florida.

出版信息

Am J Respir Crit Care Med. 2018 Aug 15;198(4):422-423. doi: 10.1164/rccm.201803-0569ED.

DOI:10.1164/rccm.201803-0569ED
PMID:29634285
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6118027/
Abstract
摘要

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本文引用的文献

1
AMP-activated Protein Kinase Phosphorylation of Angiotensin-Converting Enzyme 2 in Endothelium Mitigates Pulmonary Hypertension.AMP 激活的蛋白激酶对血管内皮细胞血管紧张素转换酶 2 的磷酸化作用可减轻肺动脉高压。
Am J Respir Crit Care Med. 2018 Aug 15;198(4):509-520. doi: 10.1164/rccm.201712-2570OC.
2
Angiotensin-converting enzyme 2 activation ameliorates pulmonary endothelial dysfunction in rats with pulmonary arterial hypertension through mediating phosphorylation of endothelial nitric oxide synthase.血管紧张素转换酶2激活通过介导内皮型一氧化氮合酶磷酸化改善肺动脉高压大鼠的肺内皮功能障碍。
J Am Soc Hypertens. 2017 Dec;11(12):842-852. doi: 10.1016/j.jash.2017.10.009. Epub 2017 Oct 28.
3
Attenuation of pulmonary ACE2 activity impairs inactivation of des-Arg bradykinin/BKB1R axis and facilitates LPS-induced neutrophil infiltration.肺组织 ACE2 活性降低可减弱无精氨酸缓激肽（des-Arg bradykinin）/BKB1R 轴的失活，并促进 LPS 诱导的中性粒细胞浸润。
Am J Physiol Lung Cell Mol Physiol. 2018 Jan 1;314(1):L17-L31. doi: 10.1152/ajplung.00498.2016. Epub 2017 Sep 21.
4
Translation of Angiotensin-Converting Enzyme 2 upon Liver- and Lung-Targeted Delivery of Optimized Chemically Modified mRNA.优化化学修饰mRNA肝脏和肺靶向递送后血管紧张素转换酶2的翻译
Mol Ther Nucleic Acids. 2017 Jun 16;7:350-365. doi: 10.1016/j.omtn.2017.04.006. Epub 2017 Apr 13.
5
The Gut, Its Microbiome, and Hypertension.肠道、其微生物组与高血压。
Curr Hypertens Rep. 2017 Apr;19(4):36. doi: 10.1007/s11906-017-0734-1.
6
Pulmonary Angiotensin-Converting Enzyme 2 (ACE2) and Inflammatory Lung Disease.肺血管紧张素转换酶2（ACE2）与炎症性肺病
Shock. 2016 Sep;46(3):239-48. doi: 10.1097/SHK.0000000000000633.
7
Role of the ACE2/Angiotensin 1-7 Axis of the Renin-Angiotensin System in Heart Failure.肾素-血管紧张素系统的ACE2/血管紧张素1-7轴在心力衰竭中的作用
Circ Res. 2016 Apr 15;118(8):1313-26. doi: 10.1161/CIRCRESAHA.116.307708.
8
Estradiol, acting through ERα, induces endothelial non-classic renin-angiotensin system increasing angiotensin 1-7 production.雌二醇通过雌激素受体α发挥作用，诱导内皮非经典肾素-血管紧张素系统增加血管紧张素1-7的生成。
Mol Cell Endocrinol. 2016 Feb 15;422:1-8. doi: 10.1016/j.mce.2015.11.004. Epub 2015 Nov 11.
9
ACE2 and Microbiota: Emerging Targets for Cardiopulmonary Disease Therapy.血管紧张素转换酶2与微生物群：心肺疾病治疗的新兴靶点
J Cardiovasc Pharmacol. 2015 Dec;66(6):540-50. doi: 10.1097/FJC.0000000000000307.
10
Molecular basis for the interaction of the mammalian amino acid transporters B0AT1 and B0AT3 with their ancillary protein collectrin.哺乳动物氨基酸转运体B0AT1和B0AT3与其辅助蛋白collectrin相互作用的分子基础。
J Biol Chem. 2015 Oct 2;290(40):24308-25. doi: 10.1074/jbc.M115.648519. Epub 2015 Aug 3.