Department of Clinical Laboratory, Affiliated People's Hospital, Jiangsu University, Zhenjiang, PR China.
Pathogen Discovery & Big Data Center, CAS Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences; University of Chinese Academy of Sciences, Shanghai 200031, PR China.
Future Microbiol. 2018 Jul;13:1029-1040. doi: 10.2217/fmb-2018-0063. Epub 2018 Apr 10.
To investigate the hand, foot and mouth disease (HFMD) epidemic in Zhenjiang, China from 2008 to 2016.
MATERIALS & METHODS: A total of 37,202 HFMD cases were investigated and 3707 nasopharyngeal swabs were detected for enterovirus RNA using RT-quantitative PCR.
We first reported a mixed pattern of HFMD seasonal epidemic with a combination of single-peak and two-peak patterns in alternate years, and the occurrence of sporadic and epidemic outbreaks of HFMD in kindergartens in Zhenjiang. Children younger than 4 years of age were highly vulnerable to HFMD, and home children and boys had higher risk to develop severe HFMD than nursery children and girls, respectively. Among tested samples, 1709 (46.1%) were detected as enterovirus RNA positive.
This study first presents the dynamic of the HFMD epidemic in Zhenjiang from 2008 to 2016.
调查 2008 年至 2016 年中国镇江手足口病（HFMD）的流行情况。
对 37202 例手足口病病例进行了调查，并采用 RT-定量 PCR 法对 3707 份鼻咽拭子进行了肠道病毒 RNA 检测。
我们首次报告了一种混合模式的 HFMD 季节性流行，在隔年出现单峰和双峰模式的组合，以及镇江幼儿园散发性和流行HFMD 暴发的发生。4 岁以下儿童对手足口病高度易感，与幼儿园儿童相比，家庭儿童和男孩发生重症手足口病的风险更高，与女孩相比。在检测的样本中，1709 份（46.1%）检测到肠道病毒 RNA 阳性。
本研究首次描述了 2008 年至 2016 年镇江手足口病流行的动态。
