Zollino M, Neri G
Istituto di Genetica Umana, Facoltà di Medicina A. Gemelli, UCSC, Roma, Italia.
Acta Haematol. 1987;78 Suppl 1:100-3. doi: 10.1159/000205912.
Chromosome fragile sites were induced in the peripheral lymphocytes of 7 donors by treatment of the cells in culture with 5-fluorodeoxyuridine and caffeine. The appearance of these fragile sites was inhibited to a large extent and in a dose-dependent manner by S-adenosylmethionine. It is possible that this methyl donor exerted its protective action through restoration of the correct level of methylation of the DNA.
通过用5-氟脱氧尿苷和咖啡因处理培养中的细胞，在7名供体的外周淋巴细胞中诱导出染色体脆性位点。S-腺苷甲硫氨酸在很大程度上以剂量依赖的方式抑制了这些脆性位点的出现。这种甲基供体可能通过恢复DNA正确的甲基化水平发挥其保护作用。
