Cohen Philip R
Department of Dermatology, University of California San Diego, La Jolla, California, USA.
Dermatol Online J. 2018 Mar 15;24(3):13030/qt6kt5n92w.
Osteoma cutis, the development of bone in the dermis and/or subcutaneous fat, can occur as either a primary or secondary condition. Perforating osteoma cutis is rare. A man with a solitary lesion of perforating osteoma cutis is described and the features of individuals with a single perforating osteoma cutis skin lesion are reviewed. A solitary lesion of either primary or secondary perforating osteoma cutis has only been observed in two men and one woman; the lesions had been present from less than one month to 19 or 20 years prior to establishing the diagnosis. The lesion was either located on the forehead (two men) or the breast (one woman). The erythematous (two lesions) or flesh-colored nodules ranged in size from 8×8 millimeters to 1.5×0.5 centimeters. Each had epidermal perforation by bone through a central area that was either crateriform or crusted or keratotic. The clinical differential diagnosis included keratoacanthoma, phlebolith, pilomatricoma, pilomatrical carcinoma, and squamous cell carcinoma. The perforating osteoma cutis lesion was successfully treated with either excision or shave biopsy without recurrence at either 10 or 12-months follow-up.
皮肤骨瘤是指在真皮和/或皮下脂肪中形成骨组织，可作为原发性或继发性疾病出现。穿通性皮肤骨瘤较为罕见。本文描述了一名患有孤立性穿通性皮肤骨瘤病变的男性，并对具有单个穿通性皮肤骨瘤皮肤病变的个体特征进行了综述。原发性或继发性穿通性皮肤骨瘤的孤立性病变仅在两名男性和一名女性中观察到；在确诊前，病变存在时间从不到一个月到19或20年不等。病变位于前额（两名男性）或乳房（一名女性）。红斑性结节（两个病变）或肤色结节大小从8×8毫米到1.5×0.5厘米不等。每个病变都有骨组织通过中央区域穿破表皮，中央区域呈火山口状、结痂状或角化状。临床鉴别诊断包括角化棘皮瘤、静脉石、毛母质瘤、毛母质癌和鳞状细胞癌。穿通性皮肤骨瘤病变通过切除或削切活检成功治疗，在10个月或12个月的随访中均无复发。
