Department of Neonatal Intensive Care, King Abdullah International Medical Research Center/King Saud Bin Abdulaziz University for Health Sciences, College of Medicine, Riyadh, Kingdom of Saudi Arabia.
Am J Perinatol. 2018 Sep;35(11):1113-1118. doi: 10.1055/s-0038-1641590. Epub 2018 Apr 10.
To assess the association of in vitro fertilization (IVF) with neonatal outcomes and duration of stay in neonatal intensive care unit (NICU) among very low birth weight (VLBW) preterm infants.
This was a cohort study of VLBW preterm infants admitted to NICU over 15 years. We assessed neonatal outcomes including composite outcome of mortality or severe morbidity, risk for major birth defects, survival without severe morbidity, and the duration of NICU stay across three birth-year epochs.
A total of 1,533 infants were eligible for data analysis. Of these, 236 were born following IVF and 1,297 were born following spontaneous conception (SC). After adjustment for baseline variables, regression analysis revealed no statistically significant differences between IVF and SC groups in terms of the composite outcome of mortality or severe morbidity, risk for major birth defects, survival without severe morbidity, or duration of NICU stay.
Among VLBW preterm infants, IVF had no detectable relationship with neonatal outcomes and duration of NICU stay. These findings can help provide guidance in professional counseling of affected families.
评估体外受精（IVF）与极低出生体重（VLBW）早产儿的新生儿结局和新生儿重症监护病房（NICU）住院时间的关系。
这是一项对 15 年来 NICU 收治的 VLBW 早产儿进行的队列研究。我们评估了新生儿结局，包括死亡率或严重发病率的复合结局、主要出生缺陷风险、无严重发病率的生存率以及 NICU 住院时间在三个出生年份期间的变化。
共有 1533 名婴儿符合数据分析条件。其中，236 名婴儿是通过 IVF 出生的，1297 名婴儿是通过自然受孕（SC）出生的。在调整基线变量后，回归分析显示，IVF 组和 SC 组在死亡率或严重发病率的复合结局、主要出生缺陷风险、无严重发病率的生存率或 NICU 住院时间方面没有统计学差异。
在 VLBW 早产儿中，IVF 与新生儿结局和 NICU 住院时间没有明显关系。这些发现可以为受影响家庭的专业咨询提供指导。
