Department of Pediatrics, Korea University Anam Hospital, Seoul, Republic of Korea; Department of Pediatrics, Seoul National University College of Medicine, Seoul, Republic of Korea.
Department of Obstetrics and Gynecology, Fertility Center of CHA Gangnam Medical Center, CHA University, Seoul, Republic of Korea.
Fertil Steril. 2019 May;111(5):962-970. doi: 10.1016/j.fertnstert.2019.01.014. Epub 2019 Mar 25.
To compare the neonatal outcomes of very low birth weight (VLBW) infants born after IVF with those of VLBW infants born after natural pregnancy (NP).
Prospective cohort study.
Not applicable.
PATIENT(S): A total of 6,871 VLBW infants born from January 2014 to December 2016.
INTERVENTION(S): None.
MAIN OUTCOME MEASURE(S): Neonatal mortality and morbidities.
RESULT(S): Of the 6,871 VLBW infants enrolled, 4,438 infants were born as singletons (IVF = 271; NP = 4,167), and 2,433 infants were born as multiplets (IVF = 1,301; NP = 1,132). After adjustment for maternal and neonatal baseline characteristics, infants born as singletons earlier than 28 weeks after IVF more frequently had high-stage retinopathy of prematurity than those born after NP, whereas infants born as multiplets between 28 and 31 weeks after IVF had fewer major congenital anomalies, high-grade intraventricular hemorrhage, and periventricular leukomalacia than those born after NP. Otherwise, no differences in mortality and neonatal outcomes were found.
CONCLUSION(S): Very low birth weight infants born as singletons after IVF had comparable neonatal outcomes to those born after NP, except for an increased risk of high-stage retinopathy of prematurity. Very low birth weight infants born as multiplets after IVF had fewer neurologic morbidities than those born after NP.
比较体外受精（IVF）后极低出生体重（VLBW）儿与自然妊娠（NP）后 VLBW 儿的新生儿结局。
前瞻性队列研究。
不适用。
2014 年 1 月至 2016 年 12 月共 6871 例 VLBW 儿。
无。
新生儿死亡率和发病率。
6871 例 VLBW 儿中，4438 例为单胎（IVF=271，NP=4167），2433 例为多胎（IVF=1301，NP=1132）。调整母亲和新生儿基线特征后，IVF 后 28 周前出生的单胎儿发生晚期早产儿视网膜病变的风险高于 NP 后出生者，而 28-31 周后出生的多胎儿发生严重先天性畸形、高级别颅内出血和脑室周围白质软化症的风险低于 NP 后出生者。其他方面，两组死亡率和新生儿结局无差异。
IVF 后出生的单胎 VLBW 儿的新生儿结局与 NP 后出生者相当，除了晚期早产儿视网膜病变的风险增加。IVF 后出生的多胎 VLBW 儿的神经发育异常发病率低于 NP 后出生者。
