Brunham Liam R, Lynch Kelsey, English Amy, Sutherland Rory, Weng Jian, Cho Raymond, Wong Graham C, Anis Aslam H, Francis Gordon A, Khan Nadia A, McManus Bruce, Wood David, Walley Keith R, Leipsic Jonathon, Humphries Karin H, Hoens Alison, Krahn Andrew D, John Mancini G B, Pimstone Simon
Department of Medicine, University of British Columbia, Vancouver, Canada.
Centre for Heart Lung Innovation, University of British Columbia, Vancouver, Canada.
Clin Cardiol. 2018 Jul;41(7):888-895. doi: 10.1002/clc.22959. Epub 2018 Jun 11.
Atherosclerotic cardiovascular disease (ASCVD) is highly heritable, particularly when it occurs at a young age. The screening of individuals with premature ASCVD, although often recommended, is not routinely performed. Strategies to address this gap in care are essential. We designed the Study to Avoid CardioVascular Events in British Columbia (SAVE BC) as a prospective, observational study of individuals with a new diagnosis of very premature ASCVD (defined as age ≤ 50 years in males and age ≤ 55 years in females) and their first-degree relatives (FDRs) and spouses. FDRs and spouses will undergo screening for cardiovascular (CV) risk factors and subclinical ASCVD using a structured screening algorithm. All subjects will be followed longitudinally for ≥10 years. The overall goal of SAVE BC is to evaluate the yield of a structured screening program for identifying individuals at risk of premature ASCVD. The primary objectives of SAVE BC are to identify and follow index cases with very premature ASCVD and their FDRs and to determine the diagnostic yield of a structured screening program for these individuals. We will collect data on CV risk factors, medication use, CV events, and healthcare costs in these individuals. SAVE BC will provide insight regarding approaches to identify individuals at risk for premature ASCVD with implications for prevention and treatment in this population.
动脉粥样硬化性心血管疾病（ASCVD）具有高度遗传性，尤其是在年轻时发病。尽管经常有人建议对患有过早ASCVD的个体进行筛查，但这并非常规操作。解决这一护理缺口的策略至关重要。我们设计了不列颠哥伦比亚省避免心血管事件研究（SAVE BC），作为一项前瞻性观察性研究，研究对象为新诊断出患有极早发性ASCVD（定义为男性年龄≤50岁，女性年龄≤55岁）的个体及其一级亲属（FDR）和配偶。FDR和配偶将使用结构化筛查算法接受心血管（CV）危险因素和亚临床ASCVD的筛查。所有受试者将进行≥10年的纵向随访。SAVE BC的总体目标是评估结构化筛查项目在识别有过早ASCVD风险个体方面的成效。SAVE BC的主要目标是识别并跟踪患有极早发性ASCVD的索引病例及其FDR，并确定针对这些个体的结构化筛查项目的诊断成效。我们将收集这些个体的CV危险因素、用药情况、CV事件和医疗费用数据。SAVE BC将为识别有过早ASCVD风险个体的方法提供见解，对该人群的预防和治疗具有启示意义。
