The Calcium Signalling Group, Department of Biochemistry and Molecular Cell Biology, University Medical Centre Hamburg-Eppendorf, Martinistrasse 52, Hamburg, 20246, Germany.
J Physiol. 2018 Jul;596(14):2735-2743. doi: 10.1113/JP275974. Epub 2018 Apr 26.
Nicotinic acid adenine dinucleotide phosphate (NAADP) is currently the most potent endogenous Ca mobilizing second messenger. Upon specific extracellular stimulation, rapid production of NAADP has been observed in different cell types from sea urchin eggs to mammalian cells. More than 20 years after the discovery of NAADP, there is still controversy surrounding its metabolism and target receptors/ion channels and organelles. This article briefly reviews recent developments in the NAADP field. Besides the metabolism of NAADP, this review focuses on assumed organelles and putative targets, e.g. ion channels, with special emphasis on ryanodine receptor type 1 (RyR1) and two-pore channels (TPCs). The role of NAADP as a Ca trigger is also discussed and the importance of NAADP in the formation of initial Ca microdomains is highlighted.
烟酰胺腺嘌呤二核苷酸磷酸（NAADP）是目前最有效的内源性钙动员第二信使。在特定的细胞外刺激下，已在从海胆卵到哺乳动物细胞等不同类型的细胞中观察到 NAADP 的快速产生。NAADP 发现 20 多年后，其代谢及其靶受体/离子通道和细胞器仍存在争议。本文简要回顾了 NAADP 领域的最新进展。除了 NAADP 的代谢，本综述还重点关注假定的细胞器和假定的靶点，例如离子通道，特别强调ryanodine 受体 1（RyR1）和双孔通道（TPCs）。还讨论了 NAADP 作为 Ca 触发物的作用，并强调了 NAADP 在初始 Ca 微区形成中的重要性。
