[3,3',5'-三碘-L-甲状腺原氨酸（反三碘甲状腺原氨酸，rT3）对大鼠血清甲状腺激素浓度的影响]
[Effect of 3,3',5' triiodo-L-Thyronine (rT3) on the serum concentration of thyroid hormones in rats].
作者信息
Chomard P, Loireau A, Dumas P, Autissier N
机构信息
Laboratoire de Chimie analytique et de Bromatologie, Faculté des Sciences Pharmaceutiques et Biologiques, Dijon.
出版信息
C R Seances Soc Biol Fil. 1987;181(4):395-400.
50, 100 or 150 micrograms/100 g body weight/day of very pure 3,3',5' triiodo-L-thyronine (rT3), obtained from a new synthetic method, was intraperitoneally administered in male Wistar rats for 5 weeks. Serum total thyroxine (T4), free thyroxine (FT4) and total 3,5,3' triiodo-L-thyronine (T3) concentrations were increased with all the doses of rT3. Free T3 (FT3) was also but non-significantly elevated. Different assumptions are put forward in order to explain this rT3 effect.
采用一种新的合成方法获得的非常纯的3,3',5'-三碘-L-甲状腺原氨酸（反式T3），以50、100或150微克/100克体重/天的剂量对雄性Wistar大鼠进行腹腔注射，持续5周。所有剂量的反式T3均使血清总甲状腺素（T4）、游离甲状腺素（FT4）和总3,5,3'-三碘-L-甲状腺原氨酸（T3）浓度升高。游离T3（FT3）也有升高，但无统计学意义。为解释这种反式T3效应提出了不同的假设。
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