He Mai, Migliori Alison, Maari Nisreen S, Mehta Niharika D
Department of Pathology and Labora, Women & Infants Hospital of Rhode Island, Providence, RI, USA.
Warren Alpert Medical School of Brown University, Providence, RI, USA.
Obstet Med. 2018 Mar;11(1):17-22. doi: 10.1177/1753495X17710129. Epub 2017 Aug 4.
Massive perivillous fibrinoid deposition is a rare placental pathology associated with significant adverse pregnancy outcome and can recur. We provide a detailed case review of a woman through 10 of her pregnancies, including 8 consecutive pregnancy losses and 2 live births. We also conducted a retrospective chart review of all massive perivillous fibrinoid deposition placenta specimens at our institution over an eight-year period. A total of 42 cases of massive perivillous fibrinoid deposition were identified from 2007 to 2015, yielding an incidence of 0.16%. Recurrence was seen in subsequent pregnancy in eight out of nine (88.9%) cases with more than one specimen. The clinical characteristics, perinatal outcomes and α-feto protein level of the 42 cases are presented. Also, presented is a review of the literature discussing placental pathology, pathogenetic mechanisms and management of this condition.
大量绒毛周围纤维素样沉积是一种罕见的胎盘病理学情况，与显著不良妊娠结局相关且可能复发。我们详细回顾了一名女性的10次妊娠情况，包括连续8次妊娠丢失和2次活产。我们还对本机构8年间所有大量绒毛周围纤维素样沉积胎盘标本进行了回顾性图表审查。2007年至2015年共识别出42例大量绒毛周围纤维素样沉积病例，发病率为0.16%。在有多个标本的9例病例中，有8例（88.9%）在后续妊娠中出现复发。呈现了这42例病例的临床特征、围产期结局和甲胎蛋白水平。此外，还对讨论这种情况的胎盘病理学、发病机制和管理的文献进行了综述。
