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[Th role of human intestinal flora on the metabolic activation of pyrolysis products].

作者信息

Patiny J, de Meester C, Wauters G

机构信息

Unité de Tératogenèse et Mutagenèse, UCL 7237, Bruxelles.

出版信息

C R Seances Soc Biol Fil. 1987;181(4):445-9.

PMID:2963682
Abstract

The role of the intestinal flora on the metabolic activation of dipyrido 1,2-a:3',2'-d imidazole compounds was investigated with the Salmonella typhimurium test system, using strain TA98. The metabolic activation mixture was obtained from cell-free extracts from E. coli, B. fragilis and Cl. perfringens. Whereas these extracts were able to activate 2-AA (used as control), the 2 and 3 amino derivatives of dipyrido [1,2-a:3',2'-d] imidazole were not revealed as mutagenic.

摘要

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