[Th role of human intestinal flora on the metabolic activation of pyrolysis products].

The role of the intestinal flora on the metabolic activation of dipyrido 1,2-a:3',2'-d imidazole compounds was investigated with the Salmonella typhimurium test system, using strain TA98. The metabolic activation mixture was obtained from cell-free extracts from E. coli, B. fragilis and Cl. perfringens. Whereas these extracts were able to activate 2-AA (used as control), the 2 and 3 amino derivatives of dipyrido [1,2-a:3',2'-d] imidazole were not revealed as mutagenic.