用诱变致癌物对DNA进行化学修饰。II. 2-氨基-6-甲基-二吡啶并[1,2-a:3',2'-d]咪唑（Glu-P-1）与DNA的碱基序列特异性结合
Chemical modification of DNA with muta-carcinogens. II. Base sequence-specific binding to DNA of 2-amino-6-methyl-dipyrido[1,2-a:3',2'-d]imidazole (Glu-P-1).
作者信息
Hashimoto Y, Shudo K
出版信息
Environ Health Perspect. 1985 Oct;62:215-8. doi: 10.1289/ehp.8562215.
Abstract
2-Amino-6-methyldipyrido[1,2-a:3',2'-d]imidazole (Glu-P-1) binds covalently to DNA after metabolic activation to give 2-(C8-guanyl)amino-6-methyldipyrido[1,2-a:3',2'-d]imidazole (Gua-Glu-P-1). The importance of the intercalative ability of the Glu-P-1 skeleton into DNA base pairs for this reaction is emphasized. The reactive form of Glu-P-1, N-acetoxy-Glu-P-1 (N-OAc-Glu-P-1), reacts preferentially at the C8 position of guanine residues in G-C-rich regions of DNA.
摘要
2-氨基-6-甲基二吡啶并[1,2-a:3',2'-d]咪唑（Glu-P-1）经代谢活化后与DNA共价结合，生成2-（C8-鸟嘌呤基）氨基-6-甲基二吡啶并[1,2-a:3',2'-d]咪唑（Gua-Glu-P-1）。强调了Glu-P-1骨架插入DNA碱基对的嵌入能力对该反应的重要性。Glu-P-1的反应形式N-乙酰氧基-Glu-P-1（N-OAc-Glu-P-1）优先在DNA富含G-C区域的鸟嘌呤残基的C8位发生反应。
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本文引用的文献
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Non-covalent interaction with DNA of the mutagens 2-amino-dipyrido[1,2-a:3',2'-d]imidazole and methyl-substituted isomers.诱变剂2-氨基-二吡啶并[1,2-a:3',2'-d]咪唑及其甲基取代异构体与DNA的非共价相互作用。
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Metabolic activation of a mutagen, 2-amino-6-methyldipyrido-[1,2-a:3',2'-d]imidazole. Identification of 2-hydroxyamino-6-methyldipyrido [1,2-a:3',2'-d]imidazole and its reaction with DNA.诱变剂2-氨基-6-甲基二吡啶并[1,2-a:3',2'-d]咪唑的代谢活化。2-羟基氨基-6-甲基二吡啶并[1,2-a:3',2'-d]咪唑的鉴定及其与DNA的反应。
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