• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

用诱变致癌物对DNA进行化学修饰。II. 2-氨基-6-甲基-二吡啶并[1,2-a:3',2'-d]咪唑（Glu-P-1）与DNA的碱基序列特异性结合

Chemical modification of DNA with muta-carcinogens. II. Base sequence-specific binding to DNA of 2-amino-6-methyl-dipyrido[1,2-a:3',2'-d]imidazole (Glu-P-1).

作者信息

Hashimoto Y, Shudo K

出版信息

Environ Health Perspect. 1985 Oct;62:215-8. doi: 10.1289/ehp.8562215.

DOI:10.1289/ehp.8562215
PMID:3910418
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1568680/
Abstract

2-Amino-6-methyldipyrido[1,2-a:3',2'-d]imidazole (Glu-P-1) binds covalently to DNA after metabolic activation to give 2-(C8-guanyl)amino-6-methyldipyrido[1,2-a:3',2'-d]imidazole (Gua-Glu-P-1). The importance of the intercalative ability of the Glu-P-1 skeleton into DNA base pairs for this reaction is emphasized. The reactive form of Glu-P-1, N-acetoxy-Glu-P-1 (N-OAc-Glu-P-1), reacts preferentially at the C8 position of guanine residues in G-C-rich regions of DNA.

摘要

2-氨基-6-甲基二吡啶并[1,2-a:3',2'-d]咪唑（Glu-P-1）经代谢活化后与DNA共价结合，生成2-（C8-鸟嘌呤基）氨基-6-甲基二吡啶并[1,2-a:3',2'-d]咪唑（Gua-Glu-P-1）。强调了Glu-P-1骨架插入DNA碱基对的嵌入能力对该反应的重要性。Glu-P-1的反应形式N-乙酰氧基-Glu-P-1（N-OAc-Glu-P-1）优先在DNA富含G-C区域的鸟嘌呤残基的C8位发生反应。

相似文献

1
Chemical modification of DNA with muta-carcinogens. II. Base sequence-specific binding to DNA of 2-amino-6-methyl-dipyrido[1,2-a:3',2'-d]imidazole (Glu-P-1).用诱变致癌物对DNA进行化学修饰。II. 2-氨基-6-甲基-二吡啶并[1,2-a:3',2'-d]咪唑（Glu-P-1）与DNA的碱基序列特异性结合
Environ Health Perspect. 1985 Oct;62:215-8. doi: 10.1289/ehp.8562215.
2
Chemical modification of DNA with muta-carcinogens. I. 3-Amino-1-methyl-5H-pyrido[4,3-b]indole and 2-amino-6-methyldipyrido[1,2-a:3',2'-d]imidazole: metabolic activation and structure of the DNA adducts.用诱变致癌物对DNA进行化学修饰。I. 3-氨基-1-甲基-5H-吡啶并[4,3-b]吲哚和2-氨基-6-甲基二吡啶并[1,2-a:3',2'-d]咪唑：DNA加合物的代谢活化与结构
Environ Health Perspect. 1985 Oct;62:209-14. doi: 10.1289/ehp.8562209.
3
Sequence selective modification of DNA with muta-carcinogenic 2-amino-6-methyldipyrido[1,2-a:3',2'-d]imidazole.
Biochem Biophys Res Commun. 1983 Nov 15;116(3):1100-6. doi: 10.1016/s0006-291x(83)80255-1.
4
Metabolic activation of glutamic acid pyrolysis products, 2-amino-6-methyldipyrido[1,2-a:3',2'-d]imidazole and 2-amino-dipyrido[1,2-a:3',2'-d]imidazole, by purified cytochrome P-450.纯化的细胞色素P-450对谷氨酸热解产物2-氨基-6-甲基二吡啶并[1,2-a:3',2'-d]咪唑和2-氨基二吡啶并[1,2-a:3',2'-d]咪唑的代谢激活作用。
Chem Biol Interact. 1981 Dec;38(1):1-13. doi: 10.1016/0009-2797(81)90149-6.
5
Modification of nucleic acids with muta-carcinogenic heteroaromatic amines in vivo. Identification of modified bases in DNA extracted from rats injected with 3-amino-1-methyl-5H-pyrido[4,3-b]indole and 2-amino-6-methyldipyrido[1,2-a3:3',2'-d]imidazole.体内用诱变致癌杂环胺对核酸进行修饰。从注射了3-氨基-1-甲基-5H-吡啶并[4,3-b]吲哚和2-氨基-6-甲基二吡啶并[1,2-a:3',2'-d]咪唑的大鼠中提取的DNA中修饰碱基的鉴定。
Mutat Res. 1982 Aug;105(1-2):9-13. doi: 10.1016/0165-7992(82)90200-7.
6
Reactions of potent mutagens, 3-amino-1-methyl-5H-pyrido[4,3-b]indole (Trp-P-2) and 2-amino-6-methyl-dipyrido[1,2-a:3',2'-d]imidazole (Glu-P-1) with nucleic acid.强诱变剂3-氨基-1-甲基-5H-吡啶并[4,3-b]吲哚（Trp-P-2）和2-氨基-6-甲基-二吡啶并[1,2-a:3',2'-d]咪唑（Glu-P-1）与核酸的反应。
Nucleic Acids Symp Ser. 1980(8):s109-12.
7
Syntheses of hydroxyamino, nitroso and nitro derivatives of Trp-P-2 and Glu-P-1, amino acid pyrolysate mutagens, and their direct mutagenicities towards Salmonella typhimurium TA98 and TA98NR.
Carcinogenesis. 1983 Dec;4(12):1547-50. doi: 10.1093/carcin/4.12.1547.
8
Transforming activity of human c-Ha-ras-1 proto-oncogene generated by the binding of 2-amino-6-methyl-dipyrido[1,2-a:3',2'-d]imidazole and 4-nitroquinoline N-oxide: direct evidence of cellular transformation by chemically modified DNA.
Jpn J Cancer Res. 1987 Mar;78(3):211-5.
9
N-acetyl derivative as the major active metabolite of 2-amino-6-methyldipyrido[1,2-a:3',2'-d]imidazole in rat bile.N-乙酰衍生物作为2-氨基-6-甲基二吡啶并[1,2-a:3',2'-d]咪唑在大鼠胆汁中的主要活性代谢物。
Mutat Res. 1986 Sep;175(1):23-8. doi: 10.1016/0165-7992(86)90140-5.
10
N-hydroxylation of carcinogenic and mutagenic aromatic amines.致癌和致突变性芳香胺的N-羟基化作用。
Environ Health Perspect. 1983 Mar;49:21-5. doi: 10.1289/ehp.834921.

本文引用的文献

1
Interaction of mutagens isolated from L-glutamic acid pyrolysate with DNA.从L-谷氨酸裂解物中分离出的诱变剂与DNA的相互作用。
Biochem Biophys Res Commun. 1980 Dec 16;97(3):968-72. doi: 10.1016/0006-291x(80)91471-0.
2
Non-covalent interaction with DNA of the mutagens 2-amino-dipyrido[1,2-a:3',2'-d]imidazole and methyl-substituted isomers.诱变剂2-氨基-二吡啶并[1,2-a:3',2'-d]咪唑及其甲基取代异构体与DNA的非共价相互作用。
Biochem Biophys Res Commun. 1980 Sep 30;96(2):611-7. doi: 10.1016/0006-291x(80)91399-6.
3
Metabolic activation of a mutagen, 2-amino-6-methyldipyrido-[1,2-a:3',2'-d]imidazole. Identification of 2-hydroxyamino-6-methyldipyrido [1,2-a:3',2'-d]imidazole and its reaction with DNA.诱变剂2-氨基-6-甲基二吡啶并[1,2-a:3',2'-d]咪唑的代谢活化。2-羟基氨基-6-甲基二吡啶并[1,2-a:3',2'-d]咪唑的鉴定及其与DNA的反应。
Biochem Biophys Res Commun. 1980 Feb 12;92(3):971-6. doi: 10.1016/0006-291x(80)90797-4.
4
Sequence selective modification of DNA with muta-carcinogenic 2-amino-6-methyldipyrido[1,2-a:3',2'-d]imidazole.
Biochem Biophys Res Commun. 1983 Nov 15;116(3):1100-6. doi: 10.1016/s0006-291x(83)80255-1.
5
Sequencing end-labeled DNA with base-specific chemical cleavages.通过碱基特异性化学切割对末端标记的DNA进行测序。
Methods Enzymol. 1980;65(1):499-560. doi: 10.1016/s0076-6879(80)65059-9.
6
An improved bacterial test system for the detection and classification of mutagens and carcinogens.一种用于检测诱变剂和致癌物并对其进行分类的改良细菌检测系统。
Proc Natl Acad Sci U S A. 1973 Mar;70(3):782-6. doi: 10.1073/pnas.70.3.782.
7
Covalent intercalative binding to DNA in relation to the mutagenicity of hydrocarbon epoxides and N-acetoxy-2-acetylaminofluorene.与烃类环氧化物和N-乙酰氧基-2-乙酰氨基芴的致突变性相关的与DNA的共价嵌入结合
Cancer Res. 1978 Oct;38(10):3247-55.