二甲双胍所致乳酸酸中毒：病例报告
Metformin-Induced Lactic Acidosis: A Case Study.
作者信息
Chowdhury Waliul, Lodhi Muhammad Uzair, Syed Intekhab Askari, Ahmed Umer, Miller Maxwell, Rahim Mustafa
机构信息
Medical Student, Department of Medicine, Raleigh General Hospital, Beckley, Wv.
Research Associate, Broad Institute of Mit and Harvard.
出版信息
Cureus. 2018 Feb 4;10(2):e2152. doi: 10.7759/cureus.2152.
Abstract
Metformin is the first line management for patients with Type 2 diabetes mellitus. Metformin-induced lactic acidosis (MALA) is a severe side effect of metformin in high doses. However, there have not been many reported cases of MALA. The threshold metformin concentration needed to induce lactic acidosis is still not fully understood. It is important for physicians to measure metformin levels upon admission in Type 2 diabetes patients who take metformin and present with suspected lactic acidosis. We present a case of a 40-year-old Caucasian male who presented with severe lactic acidosis shortly after overdosing on metformin.
摘要
二甲双胍是2型糖尿病患者的一线治疗药物。二甲双胍诱发的乳酸性酸中毒（MALA）是高剂量二甲双胍的一种严重副作用。然而，MALA的报道病例并不多。诱发乳酸性酸中毒所需的二甲双胍阈值浓度仍未完全明确。对于服用二甲双胍且疑似发生乳酸性酸中毒的2型糖尿病患者，医生在其入院时测定二甲双胍水平非常重要。我们报告一例40岁的白种男性，在过量服用二甲双胍后不久出现严重乳酸性酸中毒。
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