30 - 33周早产儿喂养方式的多中心前瞻性观察研究。
Multicentre prospective observational study of feeding practices in 30-33 weeks preterm infants.
作者信息
Kwok T C, Dorling Jon, Ojha Shalini
机构信息
Academic Division of Child Health, University of Nottingham, Nottingham, UK.
Division of Graduate Entry Medicine (Derby), School of Medicine, University of Nottingham, Nottingham, UK.
出版信息
BMJ Paediatr Open. 2017 Jul 17;1(1):e000040. doi: 10.1136/bmjpo-2017-000040. eCollection 2017.
BACKGROUND
Current evidence supports progressive feeding in preterm infants. Due to lower necrotising enterocolitis risk, recent studies suggest starting total enteral feeding from birth in 30-33 weeks preterm infants. The feasibility of this practice is unclear.
AIM
Explore feeding practices in 30-33 weeks preterm infants.
DESIGN
Prospective, multicentre, observational study recruiting 10 consecutive 30-33 weeks preterm infants from each of the eight UK hospitals.
RESULTS
Eighty infants received their first feed at median of 24 hours, achieving total enteral (without intravenous nutrition) and full feeds (≥150 ml/kg/day) at median of 5 and 8 days, respectively. Eleven infants who achieved total enteral feeding within 24 hours after birth achieved full feeds earlier (p=0.02) with shorter hospital stay (p=0.009) but were also of older gestation (p=0.004).
CONCLUSION
Current early feeding approaches in 30-33 weeks preterm infants were found to be conservative. Total enteral feeding from birth is possible in these infants but further studies are needed.
背景
目前的证据支持对早产儿进行逐步喂养。由于坏死性小肠结肠炎风险较低，近期研究表明30 - 33周的早产儿可从出生时就开始全肠道喂养。这种做法的可行性尚不清楚。
目的
探索30 - 33周早产儿的喂养方式。
设计
前瞻性、多中心观察性研究，从英国8家医院连续招募10名30 - 33周的早产儿。
结果
80名婴儿在中位数24小时时接受了首次喂养，分别在中位数5天和8天时实现了全肠道喂养（无静脉营养）和足量喂养（≥150毫升/千克/天）。11名在出生后24小时内实现全肠道喂养的婴儿更早实现了足量喂养（p = 0.02），住院时间更短（p = 0.009），但胎龄也更大（p = 0.004）。
结论
目前发现30 - 33周早产儿的早期喂养方法较为保守。这些婴儿从出生时就开始全肠道喂养是可行的，但还需要进一步研究。
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