一种通过提高细胞对活性氧的敏感性来增强光动力疗法的靶向MTH1纳米系统。
An MTH1-targeted nanosystem for enhanced PDT via improving cellular sensitivity to reactive oxygen species.
作者信息
Fan Huanhuan, Zhang Lili, Hu Xiaoxiao, Zhao Zilong, Bai Huarong, Fu Xiaoyi, Yan Guobei, Liang Li-Hui, Zhang Xiao-Bing, Tan Weihong
机构信息
Molecular Science and Biomedicine Laboratory, State Key Laboratory of Chemo/Bio-Sensing and Chemometrics, College of Chemistry and Chemical Engineering, Collaborative Innovation Center for Chemistry and Molecular Medicine, Hunan University, Changsha, 410082, China.
出版信息
Chem Commun (Camb). 2018 Apr 24;54(34):4310-4313. doi: 10.1039/c8cc01841c.
Herein, we developed a strategy to attack the cancer cell defense system against reactive oxygen species to improve photodynamic therapy efficacy with a Ce6@MSN@MTH1 siRNA nanosystem, which was demonstrated to improve cellular sensitivity to reactive oxygen species through suppressing MTH1 protein in cancer cells.
在此，我们开发了一种策略，通过Ce6@MSN@MTH1 siRNA纳米系统攻击癌细胞针对活性氧的防御系统，以提高光动力治疗的疗效，该系统被证明可通过抑制癌细胞中的MTH1蛋白来提高细胞对活性氧的敏感性。
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