Sharif Yousra, Jumah Fareed, Coplan Louis, Krosser Alec, Sharif Kassem, Tubbs R Shane
Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
Department of Anatomical Sciences, St. George's University, Grenada.
Clin Anat. 2018 Sep;31(6):812-823. doi: 10.1002/ca.23083. Epub 2018 Oct 18.
The blood-brain barrier (BBB) is the principal regulator of transport of molecules and cells into and out of the central nervous system (CNS). It comprises endothelial cells, pericytes, immune cells, astrocytes, and basement membrane, collectively known as the neurovascular unit. The development of the barrier involves many complex pathways from all the progenitors of the neurovascular unit, but the timing of its formation is not entirely known. The coordinated activities of all the components of the neurovascular unit and other tissues ensure that materials required for growth and maintenance are allowed into the CNS while extraneous ones are excluded. This review summarizes current knowledge of the anatomy, development, and physiology of the BBB, and alterations that occur in disease conditions. Clin. Anat. 31:812-823, 2018. © 2018 Wiley Periodicals, Inc.
血脑屏障（BBB）是分子和细胞进出中枢神经系统（CNS）的主要运输调节者。它由内皮细胞、周细胞、免疫细胞、星形胶质细胞和基底膜组成，统称为神经血管单元。血脑屏障的发育涉及神经血管单元所有祖细胞的许多复杂途径，但其形成时间尚不完全清楚。神经血管单元和其他组织所有成分的协同活动确保了生长和维持所需的物质能够进入中枢神经系统，同时排除外来物质。本综述总结了目前关于血脑屏障的解剖学、发育和生理学以及疾病状态下发生的改变的知识。《临床解剖学》2018年第31卷：812 - 823页。© 2018威利期刊公司。
