the State Key Laboratory and Institute of Elemento-Organic Chemistry, College of Chemistry, Nankai University, Tianjin, 300071, P. R. China.
Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Weijin Road 94#, Nankai District, Tianjin, 300071, China.
Chemistry. 2018 Jun 18;24(34):8542-8547. doi: 10.1002/chem.201801262. Epub 2018 May 16.
A simple and rapid copper-promoted aminochlorination of unactivated alkynes and alkenes with N-fluorobenzenesulfonimide (NFSI) was developed. Two series of chloroenamines and chloroamines were obtained in good to high yields. The chlorinated enamines could be obtained in a single E configuration. This reaction involved a radical process and the CuCl acted as the Cl source and NFSI as the N source.
发展了一种简单、快速的铜促进的 N-氟代苯磺酰胺（NFSI）与未活化的炔烃和烯烃的氨基氯代反应。以良好至高产率得到了两类氯代烯胺和氯代胺。所得的氯代烯胺均以单一 E-构型得到。该反应涉及自由基过程，CuCl 既是 Cl 源，也是 NFSI 的 N 源。
