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外翻式胆管吻合术:一种安全的方法,用于解决尸体供肝移植中胆管大小不匹配的问题。

Eversion Bile Duct Anastomosis: A Safe Alternative for Bile Duct Size Discrepancy in Deceased Donor Liver Transplantation.

机构信息

Simmons Transplant Institute, Baylor University Medical Center, Dallas, TX.

出版信息

Liver Transpl. 2018 Aug;24(8):1011-1018. doi: 10.1002/lt.25075.

Abstract

Bile duct size discrepancy in liver transplantation may increase the risk of biliary complications (BCs). The aim of this study was to evaluate the safety and outcomes of the eversion bile duct anastomosis technique in deceased donor liver transplantation (DDLT) with duct-to-duct anastomosis. A total of 210 patients who received a DDLT with duct-to-duct anastomosis from 2012 to 2017 were divided into 2 groups: those who had eversion bile duct anastomosis (n = 70) and those who had standard bile duct anastomosis (n = 140). BC rates were compared between the 2 groups. There was no difference in the cumulative incidence of biliary strictures (P = 0.20) and leaks (P = 0.17) between the 2 groups. The BC rate in the eversion group was 14.3% and 11.4% in the standard anastomosis group. All the BCs in the eversion group were managed with endoscopic stenting. A severe size mismatch (≥3:1 ratio) was associated with a significantly higher incidence of biliary strictures (44.4%) compared with a 2:1 ratio (8.2%; P = 0.002). In conclusion, the use of the eversion technique is a safe alternative for bile duct discrepancy in DDLT. However, severe bile duct size mismatch may be a risk factor for biliary strictures with such a technique.

摘要

肝移植中胆管大小差异可能会增加胆并发症(BCs)的风险。本研究旨在评估外翻胆管吻合技术在尸体供肝移植(DDLT)中胆管对胆管吻合中的安全性和结果。2012 年至 2017 年期间,共有 210 例接受 DDLT 胆管对胆管吻合的患者被分为两组:外翻胆管吻合组(n = 70)和标准胆管吻合组(n = 140)。比较两组的 BC 发生率。两组胆管狭窄(P = 0.20)和漏(P = 0.17)的累积发生率无差异。外翻组的 BC 发生率为 14.3%,标准吻合组为 11.4%。外翻组所有 BC 均采用内镜支架治疗。严重的大小不匹配(≥3:1 比值)与胆管狭窄的发生率显著增加(44.4%)相关,而 2:1 比值为 8.2%(P = 0.002)。总之,外翻技术在 DDLT 中胆管差异是一种安全的替代方法。然而,严重的胆管大小不匹配可能是该技术发生胆管狭窄的一个危险因素。

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