Lim Hyun Gyu, Lee Ji Hoon, Noh Myung Hyun, Jung Gyoo Yeol
J Agric Food Chem. 2018 Apr 25;66(16):3998-4006. doi: 10.1021/acs.jafc.8b00458. Epub 2018 Apr 16.
One of the great advantages of microbial fermentation is the capacity to convert various carbon compounds into value-added chemicals. In this regard, there have been many efforts to engineer microorganisms to facilitate utilization of abundant carbon sources. Recently, the potential of acetate as a feedstock has been discovered; efforts have been made to produce various biochemicals from acetate based on understanding of its metabolism. In this review, we discuss the potential sources of acetate and summarized the recent progress to improve acetate utilization with microorganisms. Furthermore, we also describe representative studies that engineered microorganisms for the production of biochemicals from acetate.
微生物发酵的一大优势在于能够将各种碳化合物转化为高附加值的化学品。在这方面，人们已做出诸多努力来改造微生物，以促进对丰富碳源的利用。最近，已发现乙酸盐作为原料的潜力；基于对其代谢的了解，人们已努力从乙酸盐生产各种生物化学品。在本综述中，我们讨论了乙酸盐的潜在来源，并总结了利用微生物提高乙酸盐利用率的最新进展。此外，我们还描述了利用工程微生物从乙酸盐生产生物化学品的代表性研究。
