Akgül Ö, Ocak S, Gündoğdu S B, Yalaza M, Güldoğan C E, Tez M
1 Department of Surgery, Ankara Numune Education and Research Hospital, Ankara, Turkey.
2 Department of Surgery, Samsun Education and Research Hospital, Samsun, Turkey.
Scand J Surg. 2018 Dec;107(4):308-314. doi: 10.1177/1457496918766724. Epub 2018 Apr 11.
: The clinicopathological demonstrations of gastric cancer vary widely between Eastern and Western countries. Turkey is situated in Europe and Middle East which acts as a bridge between east and west. We aimed to validate the two popular nomograms of east and west origin by means of patients who underwent curative surgery for gastric cancer in our country.
: Of the 202 patients diagnosed with gastric cancer between the years 2006 and 2013, 145 of these patients whose data were sufficient were included in the study. For all patients, demographic, laboratory, operative, and pathologic findings were documented. For each patient, prognostic factors were incorporated into the nomograms for estimating 5-year survival probability.
: For a Turkish cohort, the western nomogram showed a better discriminative capacity (AUC = 0.721, 95% confidence interval 0.637-0.806) and was better calibrated (the Hosmer-Lemeshow goodness-of-fit test p = 0.323), as compared to the eastern nomogram with AUC = 0.615, 95% confidence interval 0.522-0.708, and p = 0.077, respectively.
: Western nomogram was found to be more effective than eastern nomogram in prediction of estimating 5-year survival probability in patients with resectable gastric cancer in Turkish population.
东西方国家胃癌的临床病理表现差异很大。土耳其地处欧洲和中东之间，是东西方的桥梁。我们旨在通过我国接受胃癌根治性手术的患者来验证两种分别源自东西方的常用列线图。
在2006年至2013年间诊断为胃癌的202例患者中，有145例数据充足的患者被纳入研究。记录了所有患者的人口统计学、实验室、手术及病理检查结果。将每个患者的预后因素纳入列线图以估计5年生存概率。
对于土耳其队列，西方列线图显示出更好的辨别能力（AUC = 0.721，95%置信区间0.637 - 0.806）且校准效果更好（Hosmer-Lemeshow拟合优度检验p = 0.323），相比之下，东方列线图的AUC = 0.615，95%置信区间0.522 - 0.708，p = 0.077。
在预测土耳其可切除胃癌患者的5年生存概率方面，发现西方列线图比东方列线图更有效。
