Key Laboratory of Exercise and Health Sciences of Ministry of Education, Shanghai University of Sport, Shanghai, 200438, China.
Department of Epidemiology and Biostatistics, School of Public Health -- Bloomington, Indiana University, Bloomington, IN 47405, USA.
Magnes Res. 2017 Nov 1;30(4):120-132. doi: 10.1684/mrh.2018.0430.
Increasing evidence supports a role of magnesium (Mg) in skeletal muscle function. However, no systematic review or meta-analysis has summarized data on Mg supplementation in relation to muscle fitness in humans. Thus, this study aimed to quantitatively assess the effect of Mg supplementation on muscle fitness. A meta-analysis and systematic review. Medline database and other sources were searched for randomized clinical trials through July 2017. Studies that reported results regarding at least one of the following outcomes: leg strength, knee extension strength, peak torque, muscle power, muscle work, jump, handgrip, bench press weights, resistant exercise, lean mass, muscle mass, muscle strength, walking speed, Repeated Chair Stands, and TGUG were included. Measurements of the association were pooled using a fixed-effects model and expressed as weighted mean differences (WMDs) with 95% confidence intervals (95% CIs). Fourteen randomized clinical trials targeting 3 different populations were identified: athletes or physically active individuals (215 participants; mean age: 24.9 years), untrained healthy individuals (95 participants; mean age: 40.2 years), and elderly or alcoholics (232 participants; mean age: 62.7 years). The beneficial effects of Mg supplementation appeared to be more pronounced in the elderly and alcoholics, but were not apparent in athletes and physically active individuals. The results of the meta-analysis suggested that no significant improvements in the supplementation group were observed regarding isokinetic peak torque extension [WMD = 0.87; 95% CI = (-1.43, 3.18)], muscle strength [WMD = 0.87; 95% CI = (-0.12, 1.86)] or muscle power [WMD = 3.28; 95% CI = (-14.94, 21.50)]. Evidence does not support a beneficial effect of Mg supplementation on muscle fitness in most athletes and physically active individuals who have a relatively high Mg status. But Mg supplementation may benefit individuals with Mg deficiency, such as the elderly and alcoholics.
越来越多的证据表明镁（Mg）在骨骼肌功能中发挥作用。然而，目前尚无系统评价或荟萃分析总结了补充镁与人类肌肉健康相关的研究数据。因此，本研究旨在定量评估补充镁对肌肉健康的影响。 荟萃分析和系统评价。通过 2017 年 7 月之前的 Medline 数据库和其他来源搜索了随机临床试验。纳入了报告至少以下一个结果的研究：腿部力量、膝关节伸展力量、峰值扭矩、肌肉力量、肌肉做功、跳跃、握力、卧推重量、抗阻运动、瘦体重、肌肉质量、肌肉力量、步行速度、重复坐站测试和 TGUG。使用固定效应模型对关联的测量值进行合并，并表示为具有 95%置信区间（95%CI）的加权均数差（WMD）。确定了针对 3 种不同人群的 14 项随机临床试验：运动员或活跃的个体（215 名参与者；平均年龄：24.9 岁）、未经训练的健康个体（95 名参与者；平均年龄：40.2 岁）和老年人或酗酒者（232 名参与者；平均年龄：62.7 岁）。补充镁的有益效果在老年人和酗酒者中似乎更为明显，但在运动员和活跃的个体中并不明显。荟萃分析的结果表明，补充组在等速峰值扭矩伸展方面没有显著改善[WMD=0.87；95%CI=（-1.43，3.18）]、肌肉力量[WMD=0.87；95%CI=（-0.12，1.86）]或肌肉力量[WMD=3.28；95%CI=（-14.94，21.50）]。证据不支持大多数运动员和活跃个体补充镁对肌肉健康的有益影响，因为他们的镁状态相对较高。但是，镁补充可能对镁缺乏的个体有益，例如老年人和酗酒者。
