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自身免疫性抗N-甲基-D-天冬氨酸受体脑炎——基于一例临床病例的当前知识状况

Autoimmune anti-N-methyl-D-aspartate receptor encephalitis - the current state of knowledge based on a clinical case.

作者信息

Wójtowicz Rafał, Krawiec Magdalena, Orlicz Piotr

机构信息

Department of Anaesthesiology and Intensive Care, Central Teaching Hospital in Warsaw, Ministry of Interior and Administration (MI&A), Poland.

出版信息

Anaesthesiol Intensive Ther. 2018;50(1):34-39. doi: 10.5603/AIT.2018.0006.

DOI:10.5603/AIT.2018.0006
PMID:29637991
Abstract

The aim of this article is to conduct an overview of the current state of knowledge about patients presenting anti-Nmethyl- D-aspartate receptor encephalitis associated with neoplastic process, as well as diagnosis and treatment. This disease concerns mainly young women and correlates with ovarian teratoma. Most important problems seems to be the difficulties in making a proper diagnosis ensuing from the rarity of this syndrome, the period from the appearance the first symptoms to starting treatment and the correct handling of intensive care complications. There are only a few articles describing severe, complicated cases of this type of encephalitis, requiring treatment in an intensive care unit.

摘要

本文旨在对与肿瘤相关的抗N-甲基-D-天冬氨酸受体脑炎患者的当前知识现状以及诊断和治疗进行综述。这种疾病主要影响年轻女性,且与卵巢畸胎瘤相关。最重要的问题似乎是由于该综合征罕见,从出现首发症状到开始治疗的时间间隔,以及对重症监护并发症的正确处理,导致难以做出准确诊断。仅有少数文章描述了这类需要在重症监护病房进行治疗的严重、复杂型脑炎病例。

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1
Autoimmune anti-N-methyl-D-aspartate receptor encephalitis - the current state of knowledge based on a clinical case.自身免疫性抗N-甲基-D-天冬氨酸受体脑炎——基于一例临床病例的当前知识状况
Anaesthesiol Intensive Ther. 2018;50(1):34-39. doi: 10.5603/AIT.2018.0006.
2
Anti-N-methyl-D-aspartate receptor encephalitis with an imaging-invisible ovarian teratoma: a case report.伴有影像学隐匿性卵巢畸胎瘤的抗N-甲基-D-天冬氨酸受体脑炎:一例报告
J Med Case Rep. 2016 Oct 24;10(1):296. doi: 10.1186/s13256-016-1067-4.
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Anti-N-methyl-D-aspartate receptor encephalitis associated with ovarian immature teratoma.与卵巢未成熟畸胎瘤相关的抗N-甲基-D-天冬氨酸受体脑炎。
J Obstet Gynaecol Res. 2011 Dec;37(12):1883-6. doi: 10.1111/j.1447-0756.2011.01671.x. Epub 2011 Oct 14.
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[Update on anti-N-methyl-D-aspartate receptor encephalitis].[抗N-甲基-D-天冬氨酸受体脑炎的最新进展]
Nervenarzt. 2018 Jan;89(1):99-112. doi: 10.1007/s00115-017-0405-0.
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Anti-N-methyl-D-aspartate receptor encephalitis complicating ovarian teratomas: a case report.抗 N-甲基-D-天冬氨酸受体脑炎合并卵巢畸胎瘤:病例报告。
Am J Obstet Gynecol. 2011 Oct;205(4):e6-8. doi: 10.1016/j.ajog.2011.05.008. Epub 2011 May 10.
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Anti-N-methyl-D-aspartate receptor encephalitis associated with an ovarian teratoma: two cases report and anesthesia considerations.与卵巢畸胎瘤相关的抗N-甲基-D-天冬氨酸受体脑炎:两例报告及麻醉注意事项
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[Anti-N-methyl-D-aspartate receptor encephalitis associated with ovarian teratoma: Description of a case and anesthetic implications].[与卵巢畸胎瘤相关的抗N-甲基-D-天冬氨酸受体脑炎:一例病例描述及麻醉相关问题]
Rev Esp Anestesiol Reanim. 2015 Oct;62(8):468-71. doi: 10.1016/j.redar.2015.01.001. Epub 2015 Mar 21.
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Atypical presentation of anti-N-methyl-D-aspartate receptor encephalitis: two case reports.抗N-甲基-D-天冬氨酸受体脑炎的非典型表现:两例报告
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Brain on fire: anti-N-methyl-D-aspartate-receptor encephalitis associated with ovarian teratoma.脑部“着火”:与卵巢畸胎瘤相关的抗N-甲基-D-天冬氨酸受体脑炎
Conn Med. 2013 Aug;77(7):389-92.
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An Infant Born to a Mother With Anti-N-Methyl-d-Aspartate Receptor Encephalitis.一位患有抗 N-甲基-D-天冬氨酸受体脑炎的母亲所生的婴儿。
Pediatr Neurol. 2018 Feb;79:65-68. doi: 10.1016/j.pediatrneurol.2017.11.010. Epub 2017 Nov 22.

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Ovarian teratoma-associated Anti-NMDAR encephalitis in women with first-time neuropsychiatric symptoms: A meta-analysis and systematic review of reported cases.首次出现神经精神症状的女性中卵巢畸胎瘤相关抗NMDAR脑炎:病例报告的荟萃分析与系统评价
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