癌症死亡率更新及增强塑料造船业中接触苯乙烯工人的暴露反应分析。
Cancer mortality update with an exposure response analysis among styrene-exposed workers in the reinforced plastics boatbuilding industry.
机构信息
National Institute for Occupational Safety and Health, Cincinnati, Ohio.
出版信息
Am J Ind Med. 2018 Jul;61(7):566-571. doi: 10.1002/ajim.22853. Epub 2018 Apr 11.
Abstract
BACKGROUND
There is sparse and inconsistent evidence of an association between styrene exposure and cancer.
METHODS
This study examines mortality patterns in a previously studied cohort of 5201 workers employed in two Washington boat-building facilities, extending follow-up 5 years. Standardized mortality ratios (SMR) were calculated using state rates as referent. Cox regression calculated rate ratios (RR) per year employed in styrene-exposed exposed jobs.
RESULTS
No excess deaths from lymphohematopoietic cancers (LHCs) were observed (SMR: 0.99, 95%CI: 0.74-1.30) when compared to the referent population; however, the relative risk increased with duration of employment in internal analyses. Conversely, lung cancer mortality was significantly elevated (SMR: 1.24, 95%CI: 1.08-1.41), but there was no evidence of a dose-response relationship.
CONCLUSION
We found evidence that occupational exposure to styrene was associated with increased LHC risk, while no such association was observed for lung cancer.
摘要
背景
关于苯乙烯暴露与癌症之间的关联，目前仅有少量且不一致的证据。
方法
本研究对先前研究的 5201 名在华盛顿两家造船厂工作的工人队列的死亡模式进行了研究，随访时间延长了 5 年。使用州级死亡率作为参照计算标准化死亡率比 (SMR)。Cox 回归计算了暴露于苯乙烯的工作岗位上每年的超额死亡率比 (RR)。
结果
与参照人群相比，未观察到淋巴造血系统癌症 (LHC)的超额死亡 (SMR：0.99，95%CI：0.74-1.30)；然而，在内部分析中，相对风险随就业时间的延长而增加。相反，肺癌死亡率显著升高 (SMR：1.24，95%CI：1.08-1.41)，但没有证据表明存在剂量反应关系。
结论
我们发现职业暴露于苯乙烯与 LHC 风险增加有关，而肺癌则没有这种关联。
相似文献
1
Cancer mortality update with an exposure response analysis among styrene-exposed workers in the reinforced plastics boatbuilding industry.癌症死亡率更新及增强塑料造船业中接触苯乙烯工人的暴露反应分析。
Am J Ind Med. 2018 Jul;61(7):566-571. doi: 10.1002/ajim.22853. Epub 2018 Apr 11.
2
Mortality among styrene-exposed workers in the reinforced plastic boatbuilding industry.增强塑料造船行业中接触苯乙烯工人的死亡率。
Occup Environ Med. 2016 Feb;73(2):97-102. doi: 10.1136/oemed-2015-102990. Epub 2015 Nov 16.
3
Mortality patterns among workers exposed to styrene in the reinforced plastic boatbuilding industry: an update.增强塑料造船业中接触苯乙烯的工人的死亡率模式：最新情况
Am J Ind Med. 2004 Feb;45(2):165-76. doi: 10.1002/ajim.10349.
4
Lung Cancer Mortality and Styrene Exposure in the Reinforced-Plastics Boatbuilding Industry: Evaluation of Healthy Worker Survivor Bias.肺癌死亡率与增强型塑料船制造业中的苯乙烯暴露：健康工人幸存者偏差评估。
Am J Epidemiol. 2021 Sep 1;190(9):1784-1792. doi: 10.1093/aje/kwab108.
5
Cancer Incidence in Workers Exposed to Styrene in the Danish-reinforced Plastics Industry, 1968-2012.1968 - 2012年丹麦增强塑料行业接触苯乙烯工人的癌症发病率
Epidemiology. 2017 Mar;28(2):300-310. doi: 10.1097/EDE.0000000000000608.
6
Mortality Among Men and Women in the North American Synthetic Rubber Industry, 1943 to 2009.北美合成橡胶行业 1943 年至 2009 年期间男性和女性的死亡率。
J Occup Environ Med. 2019 Nov;61(11):887-897. doi: 10.1097/JOM.0000000000001688.
7
Risk of cancer in workers exposed to styrene at eight British companies making glass-reinforced plastics.在英国八家生产玻璃增强塑料的公司中，接触苯乙烯的工人患癌症的风险。
Occup Environ Med. 2015 Mar;72(3):165-70. doi: 10.1136/oemed-2014-102382. Epub 2014 Oct 30.
8
Cancer mortality of workers exposed to styrene in the U.S. Reinforced plastics and composite industry.美国增强塑料和复合材料行业中接触苯乙烯的工人的癌症死亡率。
Epidemiology. 2013 Mar;24(2):195-203. doi: 10.1097/EDE.0b013e318281a30f.
9
Styrene Exposure and Risk of Lymphohematopoietic Malignancies in 73,036 Reinforced Plastics Workers.苯乙烯暴露与 73036 名增强塑料工人中淋巴血液系统恶性肿瘤的风险。
Epidemiology. 2018 May;29(3):342-351. doi: 10.1097/EDE.0000000000000819.
10
A cohort mortality study and a case-control study of workers potentially exposed to styrene in the reinforced plastics and composites industry.一项针对增强塑料和复合材料行业中可能接触苯乙烯的工人的队列死亡率研究和病例对照研究。
Br J Ind Med. 1990 Nov;47(11):753-62. doi: 10.1136/oem.47.11.753.
引用本文的文献
1
Historical Study of Workers Exposed to Styrene in the US Reinforced Plastics and Composite Industry: Findings From a 2019 Mortality Update.美国增强塑料与复合材料行业中接触苯乙烯工人的历史研究：2019年死亡率更新结果
J Occup Environ Med. 2025 Jul 1;67(7):e452-e459. doi: 10.1097/JOM.0000000000003374. Epub 2025 Apr 10.
2
Microplastics in the Human Body: Exposure, Detection, and Risk of Carcinogenesis: A State-of-the-Art Review.人体中的微塑料：暴露、检测与致癌风险：最新综述
Cancers (Basel). 2024 Nov 1;16(21):3703. doi: 10.3390/cancers16213703.
3
Procedural application of mode-of-action and human relevance analysis: styrene-induced lung tumors in mice.方法作用和人类相关性分析的程序应用：小鼠的苯乙烯诱导肺肿瘤。
Crit Rev Toxicol. 2024 Feb;54(2):134-151. doi: 10.1080/10408444.2024.2310600. Epub 2024 Mar 5.
4
Research Recommendations for Selected IARC-Classified Agents: Impact and Lessons Learned.研究建议选定的国际癌症研究机构分类剂：影响和经验教训。
Environ Health Perspect. 2023 Oct;131(10):105001. doi: 10.1289/EHP12547. Epub 2023 Oct 30.
5
1,3-Butadiene, styrene and lymphohaematopoietic cancers among North American synthetic rubber polymer workers: exposure-response analyses.1,3-丁二烯、苯乙烯和北美合成橡胶聚合物工人的淋巴血液系统癌症：暴露反应分析。
Occup Environ Med. 2021 Dec;78(12):859-868. doi: 10.1136/oemed-2020-107197. Epub 2021 Jun 9.
6
Lung Cancer Mortality and Styrene Exposure in the Reinforced-Plastics Boatbuilding Industry: Evaluation of Healthy Worker Survivor Bias.肺癌死亡率与增强型塑料船制造业中的苯乙烯暴露：健康工人幸存者偏差评估。
Am J Epidemiol. 2021 Sep 1;190(9):1784-1792. doi: 10.1093/aje/kwab108.
7
Exposure-response assessment of cancer mortality in styrene-exposed boatbuilders.职业性接触苯乙烯人群癌症死亡率的暴露-反应关系评估
Occup Environ Med. 2020 Oct;77(10):706-712. doi: 10.1136/oemed-2020-106445. Epub 2020 May 29.
8
toxicity assessment of emitted materials collected during the manufacture of water pipe plastic linings.水烟管用塑料衬里制造过程中收集的排放物的毒性评估。
Inhal Toxicol. 2019 Mar;31(4):131-146. doi: 10.1080/08958378.2019.1621966. Epub 2019 Jun 12.
本文引用的文献
1
Cancer Incidence in Workers Exposed to Styrene in the Danish-reinforced Plastics Industry, 1968-2012.1968 - 2012年丹麦增强塑料行业接触苯乙烯工人的癌症发病率
Epidemiology. 2017 Mar;28(2):300-310. doi: 10.1097/EDE.0000000000000608.
2
Mortality among styrene-exposed workers in the reinforced plastic boatbuilding industry.增强塑料造船行业中接触苯乙烯工人的死亡率。
Occup Environ Med. 2016 Feb;73(2):97-102. doi: 10.1136/oemed-2015-102990. Epub 2015 Nov 16.
3
Risk of cancer in workers exposed to styrene at eight British companies making glass-reinforced plastics.在英国八家生产玻璃增强塑料的公司中，接触苯乙烯的工人患癌症的风险。
Occup Environ Med. 2015 Mar;72(3):165-70. doi: 10.1136/oemed-2014-102382. Epub 2014 Oct 30.
4
Cancer mortality of workers exposed to styrene in the U.S. Reinforced plastics and composite industry.美国增强塑料和复合材料行业中接触苯乙烯的工人的癌症死亡率。
Epidemiology. 2013 Mar;24(2):195-203. doi: 10.1097/EDE.0b013e318281a30f.
5
Update of the NIOSH life table analysis system: a person-years analysis program for the windows computing environment.NIOSH 寿命表分析系统更新：适用于 Windows 计算环境的人年分析程序。
Am J Ind Med. 2011 Dec;54(12):915-24. doi: 10.1002/ajim.20999. Epub 2011 Aug 30.
6
Epidemiologic studies of styrene and cancer: a review of the literature.流行病学研究中苯乙烯与癌症：文献综述。
J Occup Environ Med. 2009 Nov;51(11):1275-87. doi: 10.1097/JOM.0b013e3181ad49b2.
7
1,3-butadiene, styrene and lung cancer among synthetic rubber industry workers.丁二烯、苯乙烯与合成橡胶行业工人肺癌的关系。
J Occup Environ Med. 2009 Nov;51(11):1326-32. doi: 10.1097/JOM.0b013e3181c3c663.
8
Chemical exposures in the synthetic rubber industry and lymphohematopoietic cancer mortality.合成橡胶行业中的化学物质暴露与淋巴造血系统癌症死亡率
J Occup Environ Med. 2005 Sep;47(9):916-32. doi: 10.1097/01.jom.0000172866.16615.db.
9
Mortality patterns among workers exposed to styrene in the reinforced plastic boatbuilding industry: an update.增强塑料造船业中接触苯乙烯的工人的死亡率模式：最新情况
Am J Ind Med. 2004 Feb;45(2):165-76. doi: 10.1002/ajim.10349.
10
Attenuation of exposure-response curves in occupational cohort studies at high exposure levels.职业队列研究中高暴露水平下暴露-反应曲线的衰减。
Scand J Work Environ Health. 2003 Aug;29(4):317-24. doi: 10.5271/sjweh.737.
Zotero 插件