Graff John J, Sathiakumar Nalini, Macaluso Maurizio, Maldonado George, Matthews Robert, Delzell Elizabeth
Department of Family Medicine, Division of Occupational and Environmental Medicine, Wayne State University School of Medicine, Detroit, MI 48201, USA.
J Occup Environ Med. 2005 Sep;47(9):916-32. doi: 10.1097/01.jom.0000172866.16615.db.
This study evaluated the association between exposure to several chemicals and mortality from lymphohematopoietic cancer (LHC) among 16,579 synthetic rubber industry workers who were followed up from 1943 to 1998.
Poisson regression analyses examined LHC rates in relation to butadiene, styrene, and DMDTC exposure. Models provided maximum likelihood estimates of the relative rate for the contrast between categories of one agent, adjusting for other agents and for additional potential confounders.
Cumulative exposure to 1,3-butadiene was associated positively with all leukemia (relative rates of 1.0, 1.4, 1.2, 2.9, and 3.7, respectively, for exposures of 0, >0 to <33.7, 33.7 to <184.7, 184.7 to <425.0, and 425.0+ ppm-years), chronic myelogenous leukemia and to a lesser extent with chronic lymphocytic leukemia. Adjusting for styrene and DMDTC attenuated these associations. After controlling for butadiene, neither styrene nor DMDTC displayed a consistent exposure-response trend with all leukemia, chronic myelogenous leukemia, or chronic lymphocytic leukemia.
This study found a positive association between butadiene and leukemia that was not explained by exposure to other agents examined.
本研究评估了1943年至1998年期间接受随访的16579名合成橡胶行业工人接触多种化学物质与淋巴造血系统癌症（LHC）死亡率之间的关联。
采用泊松回归分析研究丁二烯、苯乙烯和二甲基二硫代氨基甲酸盐（DMDTC）暴露与LHC发病率的关系。模型提供了一种物质不同类别之间对比的相对率的最大似然估计值，同时对其他物质和其他潜在混杂因素进行了调整。
1,3 - 丁二烯的累积暴露与所有白血病呈正相关（暴露水平分别为0、>0至<33.7、33.7至<184.7、184.7至<425.0以及425.0 + ppm - 年时，相对率分别为1.0、1.4、1.2、2.9和3.7），与慢性粒细胞白血病呈正相关，与慢性淋巴细胞白血病的相关性较弱。对苯乙烯和DMDTC进行调整后，这些关联有所减弱。在控制丁二烯后，苯乙烯和DMDTC与所有白血病、慢性粒细胞白血病或慢性淋巴细胞白血病均未呈现一致的暴露 - 反应趋势。
本研究发现丁二烯与白血病之间存在正相关，且这种关联无法用所检测的其他物质暴露来解释。
