不育菌丝体EP - 76中铁转运的立体化学方面
Stereochemical aspects of iron transport in Mycelia sterilia EP-76.
作者信息
Adjimani J P, Emery T
机构信息
Department of Chemistry and Biochemistry, Utah State University, Logan 84322.
出版信息
J Bacteriol. 1988 Mar;170(3):1377-9. doi: 10.1128/jb.170.3.1377-1379.1988.
Chromic complexes of N,N',N''-triacetylfusarinine C have been prepared and examined for biological activity in Mycelia sterilia EP-76. The iron transport system of this organism recognizes only the lambda coordination isomer of Cr(III)-triacetylfusarinine C even though the delta configuration predominates in solution. Chromium is excreted into the medium following triacetylfusarinine C-mediated uptake of the metal. Hydrogenation of the double bonds conjugated to the hydroxamic acid functions of triacetylfusarinine C yields four chromatographically distinct ferric complexes. Two of the complexes have the lambda configuration, while the other two have the opposite (delta) configuration. The complexes differ in effectiveness as siderophores in M. sterilia EP-76, the lambda isomers being most active.
制备了N,N',N''-三乙酰伏马菌素C的铬配合物，并检测了其对不育菌丝体EP-76的生物活性。尽管在溶液中δ构型占主导，但该生物体的铁转运系统仅识别Cr(III)-三乙酰伏马菌素C的λ配位异构体。在三乙酰伏马菌素C介导的金属摄取后，铬被排泄到培养基中。与三乙酰伏马菌素C的异羟肟酸官能团共轭的双键氢化产生四种色谱上不同的铁配合物。其中两种配合物具有λ构型，而另外两种具有相反的（δ）构型。这些配合物作为不育菌丝体EP-76中的铁载体，其有效性有所不同，λ异构体最具活性。
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