Orlandi C, Rossi M, Finardi G
Department of Internal Medicine, University of Pavia School of Medicine, Italy.
Microvasc Res. 1988 Jan;35(1):21-6. doi: 10.1016/0026-2862(88)90047-7.
Knowledge of regional circulation in the skin of hypertensive patients is largely incomplete. We examined the vasodilator capacity of skin blood vessels in the foot in 20 hypertensives and in 20 age- and sex-matched normal control subjects. Vasodilator capacity was assessed by measuring skin blood flow (laser doppler flowmetry) and cutaneous vascular resistance at rest and at the peak of the postocclusive reactive hyperemia response. Skin blood flow was higher in hypertensive patients than in controls at rest (69.4 +/- 23.6 vs. 44.2 +/- 17.5 mV; P less than 0.003), but did not differ significantly after reactive hyperemia (89.2 +/- 23.5 vs 88.2 +/- 25.4 mV; N.S.). Calculated cutaneous vascular resistance was higher in controls at rest (2.99 +/- 1.06 vs 2.22 +/- 0.81 a.u.; P less than 0.3), but lower after reactive hyperemia (1.43 +/- 0.44 vs 1.64 +/- 0.43 a.u.; N.S.). Laser Doppler flowmetry is a technique suitable for studying the alterations in cutaneous microcirculation induced by hypertension. These data are compatible with structural changes in the vascular wall of hypertensive patients.
高血压患者皮肤局部循环的相关知识在很大程度上并不完整。我们检测了20名高血压患者以及20名年龄和性别匹配的正常对照者足部皮肤血管的舒张能力。通过测量静息状态下以及阻断后反应性充血反应峰值时的皮肤血流量（激光多普勒血流仪）和皮肤血管阻力来评估血管舒张能力。高血压患者静息时的皮肤血流量高于对照组（69.4±23.6对44.2±17.5 mV；P<0.003），但反应性充血后无显著差异（89.2±23.5对88.2±25.4 mV；无统计学意义）。计算得出的对照组静息时皮肤血管阻力较高（2.99±1.06对2.22±0.81任意单位；P<0.3），但反应性充血后较低（1.43±0.44对1.64±0.43任意单位；无统计学意义）。激光多普勒血流仪是一种适用于研究高血压引起的皮肤微循环改变的技术。这些数据与高血压患者血管壁的结构变化相符。
