Fauchet R, Boscher M Y, Merdrignac G, Bouhallier O, Charron D J, Paul P, Cohen D, Genetet B
Centre Régional de Transfusion Sanguine, Rennes, France.
Pathol Biol (Paris). 1987 Dec;35(10):1325-32.
The hypothesis of new class I antigens has been postulated in man, and several antigen systems have been proposed: HT (Gazit), TC (TCA, TCB) (Van Leeuwen). The present study describes a new class I antigenic marker system, expressed selectively on PHA-activated T lymphocytes and on lymphoblastoid B cell lines. These markers correlated at the cellular activation stage, have been called: human activation or HA markers. 7% of the sera from multiparous women present anti-HA antibodies. The definition of class I molecule (dimer 41K - 12K) has been established by a structural analysis of the molecule; the responsible gene, located on the 6th chromosome could be close to the HLA-A gene. The equivalence with the mouse Qa markers is postulated, but remains to be totally demonstrated.
人类中已提出了新的I类抗原假说，并提出了几种抗原系统：HT（加齐特）、TC（TCA、TCB）（范·李文）。本研究描述了一种新的I类抗原标记系统，该系统在PHA激活的T淋巴细胞和淋巴母细胞样B细胞系上选择性表达。这些标记在细胞激活阶段具有相关性，被称为：人类激活或HA标记。7%的经产妇血清中存在抗HA抗体。通过对该分子的结构分析确定了I类分子（二聚体41K - 12K）的定义；位于第6号染色体上的相关基因可能靠近HLA - A基因。推测其与小鼠Qa标记等同，但仍有待完全证实。
