Prodanov K G, Deyl Z, Jelínek J, Macek K
Department of Biomechanics, Bulgarian Academy of Sciences, Sofia.
Physiol Bohemoslov. 1987;36(6):481-5.
It has been demonstrated that both elastin and tropoelastin preparations obtained from aortae of spontaneously hypertensive rats at the stage of established hypertension differ in their amino acid composition from age-matching controls. The differences refer to an increased proportion of polar amino acids, particularly aspartic and glutamic acid (about a two-fold increase compared to the controls) and arginine and tyrosine (1.5 times the control value). On the other hand, this increase is compensated for by a decrease in the valine concentration. Furthermore, direct estimation of the number of val-pro sequence in different elastin preparations indicated a drop from 49.3 to 29.2 per 1,000 residues in normotensive controls and preparations obtained from spontaneously hypertensive rats respectively.
已经证明，从处于高血压确立阶段的自发性高血压大鼠主动脉中获得的弹性蛋白和原弹性蛋白制剂，其氨基酸组成与年龄匹配的对照不同。差异在于极性氨基酸比例增加，特别是天冬氨酸和谷氨酸（与对照相比增加约两倍）以及精氨酸和酪氨酸（为对照值的1.5倍）。另一方面，这种增加被缬氨酸浓度的降低所补偿。此外，对不同弹性蛋白制剂中缬氨酸-脯氨酸序列数量的直接估计表明，正常血压对照和从自发性高血压大鼠获得的制剂中，每1000个残基分别从49.3降至29.2。
