Deyl Z, Jelínek J, Macek K, Chaldakov G N, Vankov V N
Institute of Physiology, Czechoslovak Academy of Sciences, Prague.
Physiol Bohemoslov. 1988;37(1):33-7.
A biphasic pattern of collagen biosynthesis was found in the aortae of spontaneously hypertensive (SHR) rats; the time course of the rate of biosynthesis is similar to that described in the heart by Sen and Bumpus. In comparison to age-matched controls, collagen biosynthesis is elevated in the SHR rats, diminishes during the first fourteen weeks and rises again at the stage of established hypertension. In the period of established hypertension, the increased rate of collagen biosynthesis was associated with a pronounced rise of the collagen type I to type III ratio. On the other hand, in the pre-hypertensive stage, the proportion of collagen type III clearly exceeds the proportion of collagen type I in SHR rats.
在自发性高血压（SHR）大鼠的主动脉中发现了胶原蛋白生物合成的双相模式；生物合成速率的时间进程与森和邦普斯在心脏中描述的相似。与年龄匹配的对照组相比，SHR大鼠的胶原蛋白生物合成增加，在最初的十四周内减少，并在高血压确立阶段再次上升。在高血压确立阶段，胶原蛋白生物合成速率的增加与I型胶原蛋白与III型胶原蛋白比例的显著上升有关。另一方面，在高血压前期阶段，SHR大鼠中III型胶原蛋白的比例明显超过I型胶原蛋白的比例。
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