Bahmer F A
Universitäts-Hautklinik Homburg.
Z Hautkr. 1987 Dec 1;62(23):1662-4.
There are a number of local factors which might contribute to the induction and persistence of contact allergies in patients with chronic venous insufficiency of the lower leg and their sequelae such as stasis dermatitis and leg ulcers. Thus, the acanthotic epidermis might have a certain "reservoir function" for potential contact allergens. Furthermore, the density of epidermal Langerhans' cells is increased in areas of stasis dermatitis, and the dermis contains a high number of cells bearing HLA-DR antigens, which might act as antigen-presenting cells.
有许多局部因素可能导致小腿慢性静脉功能不全患者及其后遗症（如淤积性皮炎和腿部溃疡）发生接触性过敏并使其持续存在。因此，棘层肥厚的表皮可能对潜在的接触性过敏原具有一定的“储存功能”。此外，淤积性皮炎区域的表皮朗格汉斯细胞密度增加，真皮中含有大量携带HLA - DR抗原的细胞，这些细胞可能作为抗原呈递细胞。
