Raulin C, Frosch P J
Universitäts-Hautklinik Heidelberg.
Z Hautkr. 1987 Dec 15;62(24):1705-9.
Contact allergies to modern antimycotic agents are comparatively rare considering the high prescription rates. They may be caused by components of either the vehicle or the active ingredient. According to both the literature and our own investigations, the most important sensitizers of the vehicle are cetylstearyl alcohol and propylene glycol; as to the active substances, miconazole and nystatin are the most frequent sensitizers of the imidazole and non-imidazole group, respectively. Cross-reactions of imidazole derivatives mainly occur between miconazole and econazole. For patch testing with imidazoles, we recommend a 1% alcoholic solution of the active ingredient.
考虑到处方率较高，对现代抗真菌药物的接触性过敏相对少见。它们可能由赋形剂或活性成分的组分引起。根据文献和我们自己的调查，赋形剂中最重要的致敏剂是鲸蜡硬脂醇和丙二醇；至于活性物质，咪康唑和制霉菌素分别是咪唑类和非咪唑类中最常见的致敏剂。咪唑衍生物的交叉反应主要发生在咪康唑和益康唑之间。对于咪唑类的斑贴试验，我们推荐使用1%的活性成分酒精溶液。
